Rosiglitazone HCl is a hypoglycemic compound that stimulates insulin secretion by binding to PPAR receptors in fat cells.
FASEB J. 2017 Oct;31(10):4396-4406.
Protein kinase Cβ activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation.
Rosiglitazone HCl purchased from AbMole
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Source | The FASEB Journal (2017). Figure 1. Rosiglitazone (Abmole Bioscience, Shanghai, China) |
| Method | 3T3-L1 cell differentiation | |
| Cell Lines | 3T3-L1 cell | |
| Concentrations | 2mM | |
| Incubation Time | 3 d | |
| Results | FTO is positively regulated by PKCb. Immunoblot analyses were performed with the indicated antibodies. The quantifications of immunoblots came from 3 repeats of the experiments. |
| Molecular Weight | 393.89 |
| Formula | C18H19N3O3S.HCl |
| CAS Number | 302543-62-0 |
| Solubility (25°C) | 79 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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