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Rosiglitazone HCl is a hypoglycemic compound that stimulates insulin secretion by binding to PPAR receptors in fat cells.
FASEB J. 2017 Oct;31(10):4396-4406.
Protein kinase Cβ activates fat mass and obesity-associated protein by influencing its ubiquitin/proteasome degradation.
Rosiglitazone HCl purchased from AbMole
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Source | The FASEB Journal (2017). Figure 1. Rosiglitazone (Abmole Bioscience, Shanghai, China) |
| Method | 3T3-L1 cell differentiation | |
| Cell Lines | 3T3-L1 cell | |
| Concentrations | 2mM | |
| Incubation Time | 3 d | |
| Results | FTO is positively regulated by PKCb. Immunoblot analyses were performed with the indicated antibodies. The quantifications of immunoblots came from 3 repeats of the experiments. |
| Molecular Weight | 393.89 |
| Formula | C18H19N3O3S.HCl |
| CAS Number | 302543-62-0 |
| Solubility (25°C) | 79 mg/mL in DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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