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Lanifibranor

Cat. No. M9747
Lanifibranor Structure
Synonym:

IVA-337

Size Price Availability Quantity
10mg USD 122  USD122 In stock
25mg USD 282  USD282 In stock
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Quality Control
Biological Activity

Lanifibranor (IVA-337) is a peroxisome proliferator-activated receptors (PPAR) agonist, with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively. Lanifibranor (100 mg/kg) administration results in reduced body weight compare with vehicle controls (p<0.05).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 434.92
Formula C19H15ClN2O4S2
CAS Number 927961-18-0
Purity 100.0%
Solubility DMSO ≥ 70 mg/mL
Storage at -20°C
References

[1] Benaissa Boubia, et al. J Med Chem. Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic Clinical Candidate

[2] Cosimo Bruni, et al. Expert Rev Clin Immunol. Use of biologics and other novel therapies for the treatment of systemic sclerosis

[3] Nadira Ruzehaji, et al. Ann Rheum Dis. Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Lanifibranor, IVA-337 supplier, PPAR, inhibitors

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