Free shipping on all orders over $ 500
Lanifibranor (IVA-337) is a peroxisome proliferator-activated receptors (PPAR) agonist, with EC50s of 1.5, 0.87 and 0.21 μM for human PPARα, PPARσ and PPARγ, respectively. Lanifibranor (100 mg/kg) administration results in reduced body weight compare with vehicle controls (p<0.05).
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 434.92 |
| Formula | C19H15ClN2O4S2 |
| CAS Number | 927961-18-0 |
| Purity | 100.0% |
| Solubility | DMSO ≥ 70 mg/mL |
| Storage | at -20°C |
| Related PPAR Products |
|---|
| NXT629
NXT629 is an effective, selective and competitive PPAR-α antagonist. The IC50 value of HUMAN PPARα is 77 nM, which is higher than that of other nuclear hormone receptors, such as PPARδ, PPARγ, Erβ, GR and TRβ, with IC50 value of 6.0, 15, respectively. 15.2, 32.5 and >100 μM. |
| Inolitazone dihydrochloride
Inolitazone dihydrochloride (Efatutazone dihydrochloride) is a PPARγ agonist with high affinity, activity dependent on PPARγ, inhibiting growth, IC50 is 0.8 nM. |
| L-165041
L-165041 is a cell-permeable PPARδ agonist with Ki values of 6 nM for PPARδ and about 730 nM for PPARγ, which can induce adipocyte differentiation in NIH-PPARδ cells. |
| Alpinetin
Alpinetin is a flavonoid isolated from grass cardamom, which can activate PPAR-γ and has anti-inflammatory activity. |
| DG172 dihydrochloride
DG172 dihydrochloride is a selective PPARβ/δ antagonist with an IC50 value of 27 nM. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
