Ciglitazone is an effective selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibited the proliferation and differentiation of TH17 cells. Ciglitazone is an oral hypoglycemic agent that has been shown to be active in obese hyperglycemic animal models. Ciglitazone induces apoptosis in opossum renal epithelial cells and simultaneously activates nuclear translocation of P38 MAPK and apoptosis-inducing factor (AIF).
| Molecular Weight | 333.44 |
| Formula | C18H23NO3S |
| CAS Number | 74772-77-3 |
| Solubility (25°C) | 1eq. NaOH 33.34 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related PPAR Products |
|---|
| DSO-5a
DSO-5a is a potent, selective, orally active BB3 agonist. |
| Carfloglitazar sodium
Carfloglitazar sodium is a dual agonist of the pan peroxisome proliferator-activated receptor (PPARα/γ) with EC50 values of 1.2, 0.08, and 1.7 μM for PPARα, PPARγ, and PPARδ, respectively.It can be used in studies related to nonalcoholic steatohepatitis (NASH). |
| Seladelpar
Seladelpar is a potent, orally active, specific PPAR-δ agonist with an EC50 of 2 nM. |
| 4'-O-Methylhonokiol
4-O-Methyl honokiol is a natural neolignan isolated from Magnolia officinalis, acts as a PPARγ agonist, and inhibtis NF-κB activity, used for cancer and inflammation research. |
| 3-Phenyl-2-propen-1-ol
trans-Cinnamyl alcohol is a trans-isomer of Cinnamyl alcohol. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.
