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Ciglitazone is an effective selective PPARγ agonist (EC50=3 μM). Ciglitazone inhibited the proliferation and differentiation of TH17 cells. Ciglitazone is an oral hypoglycemic agent that has been shown to be active in obese hyperglycemic animal models. Ciglitazone induces apoptosis in opossum renal epithelial cells and simultaneously activates nuclear translocation of P38 MAPK and apoptosis-inducing factor (AIF).
| Molecular Weight | 333.44 |
| Formula | C18H23NO3S |
| CAS Number | 74772-77-3 |
| Solubility (25°C) | 1eq. NaOH 33.34 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related PPAR Products |
|---|
| GQ-16
GQ-16 is a moderate affinity ligand for the ligand-binding domain (LBD) of PPARγ, exhibiting a Ki of 160 nM. |
| SR10221
SR10221, a noncovalent inverse agonist of PPARγ, represses downstream PPARγ target genes leading to growth inhibition in bladder cancer cell lines. |
| Amorfrutin B
Amorfrutin B is a highly potent natural peroxisome proliferation-activated receptor γ (PPARγ) agonist with oral activity with Ki values of 19 nM and EC50 values of 73 nM, respectively. |
| Netoglitazone
Netoglitazone is a dual agonist of PPARα and PPARγ with antihyperglycemic activity. |
| DSO-5a
DSO-5a is a potent, selective, orally active BB3 agonist. |
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Products are for research use only. Not for human use. We do not sell to patients.
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