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Saroglitazar Magnesium

Cat. No. M13724
Saroglitazar Magnesium Structure
Size Price Availability
5mg USD 390  USD390 1-2 Weeks
10mg USD 600  USD600 1-2 Weeks
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Quality Control & Documentation
Biological Activity

Saroglitazar magnesium is a novel peroxisome proliferator-activated receptor (PPAR) agonist with predominant PPARα and moderate PPARγ activity with EC50 values of 0.65 pM and 3 nM in HepG2 cells, respectively.

Chemical Information
Molecular Weight 901.42
CAS Number 1639792-20-3
Solubility (25°C) DMSO 90 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Samer Gawrieh, et al. Hepatology. Saroglitazar, a PPAR-α/γ Agonist, for Treatment of NAFLD: A Randomized Controlled Double-Blind Phase 2 Trial

[2] Divya P Kumar, et al. Sci Rep. The PPAR α/γ Agonist Saroglitazar Improves Insulin Resistance and Steatohepatitis in a Diet Induced Animal Model of Nonalcoholic Fatty Liver Disease

[3] Poonam Giri, et al. Eur J Pharm Sci. Lack of inhibition of CYP2C8 by saroglitazar magnesium: In vivo assessment using montelukast, rosiglitazone, pioglitazone, repaglinide and paclitaxel as victim drugs in Wistar rats

[4] Mukul R Jain, et al. Liver Int. Dual PPARα/γ agonist saroglitazar improves liver histopathology and biochemistry in experimental NASH models

[5] Shashank R Joshi. Expert Opin Pharmacother. Saroglitazar for the treatment of dyslipidemia in diabetic patients

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Keywords: Saroglitazar Magnesium supplier, PPAR, inhibitors, activators


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