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Saroglitazar

Cat. No. M9195

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Saroglitazar Structure
Size Price Availability Quantity
25mg USD 850  USD850 In stock
50mg USD 1300  USD1300 In stock
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Quality Control & Documentation
Biological Activity

Saroglitazar is novel first dual PPAR agonist at the subtypes α (alpha) and γ (gamma) of the peroxisome proliferator-activated receptor (PPAR). Agonist action at PPARα lowers high blood triglycerides, and agonist action on PPARγ improves insulin resistance and consequently lowers blood sugar.

In vivo, in db/db mice, 12-day treatment with Saroglitazar (0.01-3 mg/kg per day, orally) causes dose-dependent reductions in serum triglycerides (TG), free fatty acids (FFA), and glucose. The ED50 for these effects is found to be 0.05, 0.19, and 0.19 mg/kg, respectively with highly significant (91%) reduction in serum insulin and AUC-glucose following oral glucose administration (59%) at 1 mg/kg dose.

Chemical Information
Molecular Weight 439.57
Formula C25H29NO4S
CAS Number 495399-09-2
Form Oil
Solubility (25°C) DMSO: ≥ 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jain MR, et al. Pharmacol Res Perspect. Saroglitazar, a novel PPARα/γ agonist with predominant PPARα activity, shows lipid-lowering and insulin-sensitizing effects in preclinical models.

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Keywords: Saroglitazar supplier, PPAR, inhibitors, activators

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