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Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1). Etomoxir binds irreversibly to the catalytic site of CPT-1 inhibiting its activity, but also upregulates fatty acid oxidation enzymes.
In vivo, Rats treated with Etomoxir (injected daily for 8 days at 20 mg/kg of body mass) display a 44% reduced cardiac CPT-I activity. The treatment of Lewis rats for 8 days with 20 mg/kg Etomoxir does not alter blood glucose, which is in line with comparable etomoxir-feeding studies.
| Molecular Weight | 326.82 |
| Formula | C17H23ClO4 |
| CAS Number | 124083-20-1 |
| Solubility (25°C) | DMSO: ≥ 40 mg/mL |
| Storage | -20°C, protect from light, sealed |
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