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Etomoxir is a potent inhibitor of carnitine palmitoyltransferase-I (CPT-1). Etomoxir binds irreversibly to the catalytic site of CPT-1 inhibiting its activity, but also upregulates fatty acid oxidation enzymes.
In vivo, Rats treated with Etomoxir (injected daily for 8 days at 20 mg/kg of body mass) display a 44% reduced cardiac CPT-I activity. The treatment of Lewis rats for 8 days with 20 mg/kg Etomoxir does not alter blood glucose, which is in line with comparable etomoxir-feeding studies.
Patent. CN116492329A 2023 Jul 28.
Patent. CN116492329A
Etomoxir purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | SF188 glioblastoma cells |
| Preparation method | Cells were harvested and suspended at 1 × 10^6 cells/ml in phosphate buffered saline (PBS) supplementedwith 25 mM glutamine and 6 mM L-glutamine. They were and treated with 1 mM etomoxir for 25 minutes. |
| Concentrations | 1 mM |
| Incubation time | 25 minutes |
| Animal Experiment | |
|---|---|
| Animal models | Male BALB/c nude mice |
| Formulation | Not mentioned |
| Dosages | 40 mg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 326.82 |
| Formula | C17H23ClO4 |
| CAS Number | 124083-20-1 |
| Solubility (25°C) | DMSO: ≥ 40 mg/mL |
| Storage | -20°C, protect from light, sealed |
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