Trospium chloride is a competitive muscarinic cholinergic receptor antagonist. Trospium chloride is a quaternary ammonium compound. Trospium chloride dosed 20 mg twice daily, is significantly superior to placebo in improving cystometric parameters, reducing urinary frequency, reducing incontinence episodes, and increasing urine volume per micturition. In active-controlled trials, trospium chloride was at least equivalent to immediate-release formulations of oxybutynin and tolterodine in efficacy and tolerability.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Solubility||Water 80 mg/mL
DMSO ≥ 20 mg/mL
Trospium chloride for the treatment of overactive bladder with urge incontinence
Devada Singh-Franco, et al. Clin Ther. 2005 May;27(5):511-30. PMID: 15978301.
Trospium chloride in the management of overactive bladder
Eric S Rovner. Drυgs. 2004;64(21):2433-46. PMID: 15482001.
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