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Trospium chloride

Cat. No. M3331
Trospium chloride Structure
Size Price Availability Quantity
10mM*1mL USD 63  USD70 In stock
25mg USD 72  USD80 In stock
50mg USD 108  USD120 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Trospium chloride is a competitive muscarinic cholinergic receptor antagonist. Trospium chloride is a quaternary ammonium compound. Trospium chloride dosed 20 mg twice daily, is significantly superior to placebo in improving cystometric parameters, reducing urinary frequency, reducing incontinence episodes, and increasing urine volume per micturition. In active-controlled trials, trospium chloride was at least equivalent to immediate-release formulations of oxybutynin and tolterodine in efficacy and tolerability.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 427.96
Formula C25H30NO3.Cl
CAS Number 10405-02-4
Purity >99%
Solubility Water 80 mg/mL
DMSO ≥ 20 mg/mL
Storage at -20°C

Trospium chloride for the treatment of overactive bladder with urge incontinence
Devada Singh-Franco, et al. Clin Ther. 2005 May;27(5):511-30. PMID: 15978301.

Trospium chloride in the management of overactive bladder
Eric S Rovner. Drυgs. 2004;64(21):2433-46. PMID: 15482001.

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Keywords: Trospium chloride supplier, AChR/AChE, inhibitors

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