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Trospium chloride

Cat. No. M3331
Trospium chloride Structure
Size Price Availability Quantity
10mM*1mL in DMSO USD 50  USD50 In stock
50mg USD 40  USD40 In stock
100mg USD 50  USD50 In stock
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Quality Control & Documentation
Biological Activity

Trospium chloride is a competitive muscarinic cholinergic receptor antagonist. Trospium chloride is a quaternary ammonium compound. Trospium chloride dosed 20 mg twice daily, is significantly superior to placebo in improving cystometric parameters, reducing urinary frequency, reducing incontinence episodes, and increasing urine volume per micturition. In active-controlled trials, trospium chloride was at least equivalent to immediate-release formulations of oxybutynin and tolterodine in efficacy and tolerability.

Chemical Information
Molecular Weight 427.96
Formula C25H30NO3.Cl
CAS Number 10405-02-4
Solubility (25°C) Water 90 mg/mL
DMSO 30 mg/mL
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Devada Singh-Franco, et al. Clin Ther. Trospium chloride for the treatment of overactive bladder with urge incontinence

[2] Eric S Rovner. Drυgs. Trospium chloride in the management of overactive bladder

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