| Cat.No. | Name | Information |
|---|---|---|
| M8888 | Donepezil | Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively. |
| M7227 | EVP-6124 hydrochloride | EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs). |
| M5683 | Glycopyrrolate | Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
| M3601 | Donepezil hydrochloride | Donepezil is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM , respectively. |
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
| M58539 | AT 1001 | AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) with Ki of 2.64 nM. |
| M58356 | Spinosad | Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. |
| M55213 | Zanapezil | Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor, it has potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM). |
| M54846 | Tacrine | Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate agent. |
| M53704 | α-Bungarotoxin | α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). |
| M52776 | α-Conotoxin AuIB | α-Conotoxin AuIB, a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist, blocks α3β4 nAChRs expressed in Xenopus oocytes with an IC50 of 0.75 μM. |
| M49428 | α-Conotoxin AuIB TFA | α-Conotoxin AuIB TFA is a potent and selective α3β4 nicotinic acetylcholine receptor (nAChR) antagonist that blocks α3β4 nAChRs expressed in African clawed toad oocytes with an IC50 of 0.75 μM. |
| M49427 | α-Conotoxin MII TFA | α-Conotoxin MII TFA, a natural product isolated from the sea snail Conus magus, can effectively inhibit the α3β2 subunit of the nAChR receptor, with an IC50 value of 0.5 nM. In addition, α-Conotoxin MII TFA can effectively inhibit the activity of β3-containing neuro-nicotinic receptor. |
| M49426 | α-Conotoxin PIA TFA | α-Conotoxin PIA TFA is a nicotinic acetylcholine receptor (nAChR) antagonist that targets the nAChR, which contains both the α6 and α3 subunits. α-Conotoxin PIA TFA can be used in studies related to Parkinson's disease and schizophrenia. |
| M49425 | α-Conotoxin GI TFA | α-Conotoxin GI TFA is a short peptide toxin isolated from the venom of Conus geographus that has a high affinity for nAChR. α-Conotoxin GI TFA has similar activity to neuromuscular blocking agents. |
| M43973 | A-582941 dihydrochloride | A-582941 dihydrochloride is a potent, selective, partial agonist of α7 nAChR across the blood-brain barrier, with Ki values of 10.8 nM in rat meninges and 16.7 nM in human frontal cortex.Additionally, A-582941 dihydrochloride binds to human 5- and 5HT3 receptors with a Ki value of 150 nM. In addition, A-582941 dihydrochloride can bind to human 5- HT3 receptors at a Ki value of 150 nM. A-582941 dihydrochloride can be used in studies of various neurodegenerative diseases and cognitive deficits. |
| M42645 | Isogarcinol | Isogarcinol (Cambogin) is a potent AChE and BChE inhibitor, with IC50 values of 1.13 and 8.30 μM, respectively. |
| M39192 | Chikusetsusaponin Ib | Chikusetsusaponin Ib has anti-Alzheimer's disease activity and is a potent AChE inhibitor. |
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