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AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

Inhibitors

Cat.No.  Name Information
M2489 Carbachol chloride Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.
M11348 Garcinol Garcinol is a kind of polyisoprene diphenylketone extracted from Garcinia japonicum. It has anticholinesterase properties for AChE and butyrylcholinesterase (BChE) with IC50 of 0.66 µM and 7.39 µM, respectively. Garcinol also inhibited histone acetyltransferases (HATs, IC50=7 μM) and P300 /CPB related factors (PCAF, IC50=5 μM). Garcinol has anti-inflammatory and anticancer activities.
M10659 Picfeltarraenin IV Picfeltarraenin IV is an acetylcholinesterase (AChE) inhibitor, which is obtained from Picriafel-terrae Lour (P.fel-terrae).
M10655 Picfeltarraegenin X Picfeltarraenin X is an AChE inhibitor, which is a triterpenoid isolated from Picria fel-terrae Lour.
M10623 Dehydronuciferine Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL
M10619 Rhodiosin Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL.
M10616 Picfeltarraenin IA Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor.
M10294 Scopolamine hydrobromide trihydrate Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM.
M10154 Choline Glycerophosphate Choline Glycerophosphate is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue.
M9768 MK-7622 MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator.
M9590 Acotiamide dihydrochloride Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE).
M9562 Huperzine A Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb.
M9519 Nelonicline Nelonicline (ABT-126) is a nicotinic acetylcholine receptor agonist.
M8888 Donepezil Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively.
M7853 Ipratropium bromide monohydrate Nonselective muscarinic acetylcholine receptor antagonist; bronchodilator.
M7585 Atropine Atropine (Tropine tropate) is a competitive nonselective antagonist at central and peripheral muscarinic acetylcholine receptors.
M7227 EVP-6124 hydrochloride EVP-6124 hydrochloride) is a novel partial agonist of α7 neuronal nicotinic acetylcholine receptors (nAChRs).
M6273 Varenicline tartrate Varenicline Tartrate is a nicotinic AChR partial agonist, used to treat nicotine addiction.
M6268 Varenicline Varenicline (CP 526555) is a selective α4β2 nicotinic receptor partial agonist, it stimulates nicotine receptors more weakly than nicotine itself does.
M6127 TD-4208 TD-4208 is a novel and potent muscarinic receptor antagonist that has a high affinity and long residence time at the M3 receptor, and demonstrates in vitro kinetic selectivity for M3 over M2 muscarinic receptor subtype and no meaningful off-target activity.
M6040 Tropicamide Tropicamide (Ro 1-7683) is an anticholinergic and a muscarinic receptor subtype M4-preferring antagonist with IC50 of 8.0 nM.



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