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AChR/AChE Acetylcholine Receptors/Acetylcholinesterase

Cat.No.  Name Information
M3470 Oxybutynin Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties.
M3190 PNU-282987 PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM.
M2489 Carbachol chloride Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor.
M55213 Zanapezil Zanapezil (TAK-147) is a potent, reversible and selective acetylcholine esterase (AChE) inhibitor, it has potent and reversible inhibition of AChE activity in homogenates of the rat cerebral cortex (IC50=51.2 nM).
M54846 Tacrine Tacrine is a potent acetylcholinesterse (AChE) inhibitor (IC50=109 nM), also acting as a CYP1A2 substrate agent.
M53704 α-Bungarotoxin α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs).
M49427 α-Conotoxin MII TFA α-Conotoxin MII TFA, a natural product isolated from the sea snail Conus magus, can effectively inhibit the α3β2 subunit of the nAChR receptor, with an IC50 value of 0.5 nM. In addition, α-Conotoxin MII TFA can effectively inhibit the activity of β3-containing neuro-nicotinic receptor.
M49426 α-Conotoxin PIA TFA α-Conotoxin PIA TFA is a nicotinic acetylcholine receptor (nAChR) antagonist that targets the nAChR, which contains both the α6 and α3 subunits. α-Conotoxin PIA TFA can be used in studies related to Parkinson's disease and schizophrenia.
M49425 α-Conotoxin GI TFA α-Conotoxin GI TFA is a short peptide toxin isolated from the venom of Conus geographus that has a high affinity for nAChR. α-Conotoxin GI TFA has similar activity to neuromuscular blocking agents.
M43973 A-582941 dihydrochloride A-582941 dihydrochloride is a potent, selective, partial agonist of α7 nAChR across the blood-brain barrier, with Ki values of 10.8 nM in rat meninges and 16.7 nM in human frontal cortex.Additionally, A-582941 dihydrochloride binds to human 5- and 5HT3 receptors with a Ki value of 150 nM. In addition, A-582941 dihydrochloride can bind to human 5- HT3 receptors at a Ki value of 150 nM. A-582941 dihydrochloride can be used in studies of various neurodegenerative diseases and cognitive deficits.
M30915 Pilocarpine  Pilocarpine is a selective M3-type muscarinic acetylcholine receptor (M3 muscarinic receptor) agonist.
M30312 Physostigmine Physostigmine (Eserine) is a reversible acetylcholinesterase (AChE) inhibitor. Physostigmine can crosses the blood-brain barrier and stimulates central cholinergic neurotransmission. Physostigmine can reverse memory deficits in transgenic mice with Alzheimer's disease. Physostigmine is also an antidote for anticholinergic poisoning.
M28721 Sofpironium bromide Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes.
M28563 Penehyclidine hydrochloride Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation.
M28356 Xanomeline oxalate Xanomeline oxalate (LY246708 oxalate) is a potent and selective muscarinic receptor agonist (SMRA) and stimulates phosphoinositide hydrolysis in vivo. Xanomeline oxalate can be used for the research of Alzheimer’s disease.
M25486 (S)-(+)-Dimethindene maleate (S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48).
M22466 Emraclidine (CVL-231) Emraclidine (CVL-231) is a potential best-in-class, muscarinic M4 receptor-positive modulator (PAM) that crosses the blood-brain barrier.Emraclidine can be used in studies related to neurological disorders.
M21720 ZSET1446 (ST101) ZSET1446 (ST101) is a novel cognitive enhancer that activates T-type voltage-gated calcium channels (VGCCs), and it significantly improves learning deficits in various types of Alzheimer disease (AD) models.
M21560 Racanisodamine Racanisodamine (7 beta Hydroxyhyoscyamine) is a racemic substance with similar pharmacological effects. Racanisodamine is a vasoactive Chinese herbal extract used to study acute disseminated intravascular coagulation in patients with bacterial shock.
M20984 Varenicline dihydrochloride Varenicline (CP 526555, Chantix, Champix) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation.

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