| Cat.No. | Name | Information |
|---|---|---|
| M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M5683 | Glycopyrrolate | Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
| M29410 | Benzgalantamine | Benzgalantamine (GLN-1062) is a pro-agent of galantamine, it is used for the research for Alzheimer’s disease. |
| M28721 | Sofpironium bromide | Sofpironium bromide (BBI 4000) is an anticholinergic agent used in the study of primary axillary hyperhidrosis (PAH). Sofpironium bromide reduces sweating by inhibiting M3 muscarinic receptors in eccrine glands at the application site. Sofpironium bromide also has a high afnity for the M1, M2, M4 and M5 subtypes. |
| M28563 | Penehyclidine hydrochloride | Penehyclidine (Penequinine) hydrochloride, a anticholinergic agent, is a selective antagonist of M1 and M3 receptors. Penehyclidine hydrochloride activates NF-kβ in lung tissue and inhibits the release of inflammatory factors. Penehyclidine hydrochloride can alleviate the pulmonary inflammatory response in rats with chronic obstructive pulmonary disease (COPD) undergoing mechanical ventilation. |
| M28522 | Levamisole | Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the α3β2 (EC50=300 μM) and α3β4 (EC50=100 μM) subtype of nAChRs. Orally active. |
| M28356 | Xanomeline oxalate | Xanomeline oxalate (LY246708 oxalate) is a potent and selective muscarinic receptor agonist (SMRA) and stimulates phosphoinositide hydrolysis in vivo. Xanomeline oxalate can be used for the research of Alzheimer’s disease. |
| M25486 | (S)-(+)-Dimethindene maleate | (S)-(+)-Dimethindene maleate, an enantiomer, is a potent M2-selective muscarinic receptor antagonist (pA2 = 7.86/7.74; pKi = 7.78). (S)-(+)-Dimethindene maleate also is a histamine H1 receptor antagonist (pA2 = 7.48). |
| M22466 | Emraclidine (CVL-231) | Emraclidine (CVL-231) is a potential best-in-class, muscarinic M4 receptor-positive modulator (PAM) that crosses the blood-brain barrier.Emraclidine can be used in studies related to neurological disorders. |
| M21720 | ZSET1446 (ST101) | ZSET1446 (ST101) is a novel cognitive enhancer that activates T-type voltage-gated calcium channels (VGCCs), and it significantly improves learning deficits in various types of Alzheimer disease (AD) models. |
| M21560 | Racanisodamine | Racanisodamine (7 beta Hydroxyhyoscyamine) is a racemic substance with similar pharmacological effects. Racanisodamine is a vasoactive Chinese herbal extract used to study acute disseminated intravascular coagulation in patients with bacterial shock. |
| M20984 | Varenicline dihydrochloride | Varenicline (CP 526555, Chantix, Champix) dihydrochloride is a potent, partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR with EC50 of 2.3 μM and 55 μM, respectively. Varenicline dihydrochloride is a potent, full agonist of α7 nAChRs with EC50 of 18 μM. Varenicline is a prescription medication used for smoking cessation. |
| M19243 | Coclaurine | Coclaurine is a class of tetrahydroisoquinoline alkaloids isolated from Sarcopetalum harveyanum. Coclaurine is a nicotinic acetylcholine receptor (nAChRs) antagonist. |
| M14955 | Acetylcholine iodide | Acetylcholine iodide (ACh iodide) is a common neurotransmitter found in the central and peripheral nerve system. |
| M14551 | Tacrine hydrochloride (hydrate) | Tacrine hydrochloride (hydrate) is an inhibitor of both acetyl (AChE) and butyryl-cholinestrase (BChE) with IC50s of 31 nM and 25.6 nM, respectively. |
| M14548 | Galanthamine | Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM. |
| M14547 | Epiberberine chloride | Epiberberine chloride is an alkaloid isolated from Coptis chinensis, acts as a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. |
| M14008 | Umeclidinium bromide | Umeclidinium bromide is a novel mAChR antagonist. The affinity (Ki) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM. |
| M14003 | Clozapine N-oxide dihydrochloride | Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. |
| M11552 | DREADD agonist 21 | DREADD Agonist 21 is an effective agonist for human muscarinic acetylcholine M3 receptor (hM3Dq) (EC50=1.7 nM). |
| M11551 | Deschloroclozapine | Deschloroclozapine is an effective, high affinity, selective, metabolically stable agonist based on muscarinic DREADDs. The Ki binding values of Deschloroclozapine to DREADD receptor subtypes hM3Dq and hM4Di were 6.3 and 4.2 nM, respectively. |
| M11534 | Altenuene | Altenuene belongs to plant extraction compounds, hydrophilic plant extracts can choose water, methanol, ethanol as solvents, lipophilic plant extracts please choose petroleum ether, benzene and other organic solvents. |
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