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JHU37160 

Cat. No. M29552

All AbMole products are for research use only, cannot be used for human consumption.

JHU37160  Structure

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Quality Control & Documentation
Biological Activity

JHU37160 is a potent and brain-penetrant DREADD agonist, with EC50s of 18.5 nM and 0.2 nM for hM3Dq and hM4Di DREADDs in HEK-293 cells, respectively. JHU37160 exhibits selective [3H]Clozapine displacement from DREADDs and not from other Clozapine-binding sites in mice brain tissue.

Chemical Information
Molecular Weight 358.84
Formula C19H20ClFN4
CAS Number 2369979-68-8
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Jacqueline Van Savage, et al. Behav Brain Res. High dose administration of DREADD agonist JHU37160 produces increases in anxiety-like behavior in male rats

[2] Jana Desloovere, et al. Neurotherapeutics. Chemogenetic Seizure Control with Clozapine and the Novel Ligand JHU37160 Outperforms the Effects of Levetiracetam in the Intrahippocampal Kainic Acid Mouse Model

[3] Jordi Bonaventura, et al. Nat Commun. High-potency ligands for DREADD imaging and activation in rodents and monkeys

[4] Michele L Singer, et al. J Neurophysiol. Chemogenetic activation of hypoglossal motoneurons in a mouse model of Pompe disease

[5] Kate A Lawson, et al. bioRxiv. A head-to-head comparison of two DREADD agonists for suppressing operant behavior in rats via VTA dopamine neuron inhibition

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Keywords: JHU37160  supplier, AChR/AChE, inhibitors, activators

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