Aclidinium Bromide is a novel long-acting muscarinic antagonist that binds to the human muscarinic receptors AChR M1, M2, M3, M4, and M5 with Ki values of 0.1 nM, 0.14 nM, 0.14 nM, 0.21 nM, and 0.16 nM, respectively. It can be used in chronic obstructive pulmonary disease (COPD) studies.
| Molecular Weight | 564.55 |
| Formula | C26H30NO4S2.Br |
| CAS Number | 320345-99-1 |
| Solubility (25°C) | DMSO 43 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[3] Han Ni, et al. Aclidinium bromide for stable chronic obstructive pulmonary disease
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