| Cat.No. | Name | Information |
|---|---|---|
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M10830 | Corynantheine | Corynantheine (Hirsuteine) is an indole alkaloid extracted from Uncaria rhynchophylla. Corynantheine (Hirsuteine) antagonizes nicotine-mediated dopamine release non-competitively by blocking ion permeation through nicotinic receptor channel complexes. |
| M10659 | Picfeltarraenin IV | Picfeltarraenin IV is an acetylcholinesterase (AChE) inhibitor, which is obtained from Picriafel-terrae Lour (P.fel-terrae). |
| M10655 | Picfeltarraegenin X | Picfeltarraenin X is an AChE inhibitor, which is a triterpenoid isolated from Picria fel-terrae Lour. |
| M10623 | Dehydronuciferine | Dehydronuciferine is isolated from the leaves of Nelumbo nucifera Gaertn, a acetylcholinesterase (AChE) inhibitor with an IC50 of 25 μg/mL |
| M10619 | Rhodiosin | Rhodiosin, isolated from the root of Rhodiola crenulata, is a specific non-competitive cytochrome P450 2D6 inhibitor with an IC50 of 0.420 μM and a Ki of 0.535 μM. Rhodiosin exhibits potent, dose-dependent inhibitory effects on acetylcholinesterase (AChE) with IC50 ranged from 57.50 to 2.43 μg/mL. |
| M10616 | Picfeltarraenin IA | Picfeltarraenin IA, a triterpenoid obtained from Picriafel-terrae Lour (P.fel-terrae), is an acetylcholinesterase (AChE) inhibitor. |
| M10294 | Scopolamine hydrobromide trihydrate | Scopolamine hydrobromide trihydrate is a competitive muscarinic acetylcholine receptor with an IC50 of 55.3 ± 4.3 nM. |
| M10154 | Choline Glycerophosphate | Choline Glycerophosphate is a precursor in the biosynthesis of brain phospholipids and increases the bioavailability of choline in nervous tissue. |
| M9768 | MK-7622 | MK-7622 is a cholinesterase inhibitor, it is also a muscarinic M1 receptor positive allosteric modulator. |
| M9607 | VU0119498 | VU0119498 is a M1 muscarinic receptor agonist (EC50 = 3.1 μM) and pan mAChR M3, M5 positive allosteric modulator (PAM). |
| M9606 | VU0238441 | VU0238441 is a potent agonist of Muscarinic acetylcholine receptor M5 (human) with EC50 of 2.1μM. |
| M9590 | Acotiamide dihydrochloride | Acotiamide is a potent, selective and reversible inhibitor of human and canine stomach-derived acetylcholinesterase (AChE). |
| M9562 | Huperzine A | Huperzine A is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor extracted from traditional Chinese herb. |
| M9519 | Nelonicline | Nelonicline (ABT-126) is a nicotinic acetylcholine receptor agonist. |
| M9058 | Varenicline hydrochloride | Varenicline hydrochloride is a potent partial agonist of α4β2 nicotinic acetylcholine receptor (nAChR) and α3β4 nAChR, with EC50s of 2.3 μM and 55 μM, respectively. In addition, Varenicline hydrochloride is also a potent full agonist of α7 nAChRs. In addition, Varenicline hydrochloride is a potent full α7 nAChRs agonist with an EC50 of 18 μM. |
| M8888 | Donepezil | Donepezil(E 2020) is a specific and potent AChE inhibitor for bAChE and hAChE with IC50 of 8.12 nM and 11.6 nM, respectively. |
| M8846 | VU0238429 | VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. |
| M8342 | AF-DX 116 | AF-DX 116 is a selective M2 muscarinic acetylcholine receptor antagonist. |
| M8303 | Azimilide dihydrochloride | Azimilide is an investigational class III anti-arrhythmic compound that blocks fast and slow components of the delayed rectifier cardiac potassium channels. |
| M8028 | Propantheline bromide | Propantheline bromide is an orally active mAChR antagonist that inhibits acetylcholine action at postganglionic synapses, and can be used in studies related to smooth muscle dysfunction as well as gastrointestinal spasms. |
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