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Clozapine N-oxide dihydrochloride is a major metabolite of Clozapine and a human muscarinic designer receptors (DREADDs) agonist. Clozapine N-oxide dihydrochloride activates the DREADD receptor hM3Dq and hM4Di. Clozapine N-oxide dihydrochloride can cross the blood-brain barrier. Clozapine is a potent dopamine antagonist and also a potent and selective muscarinic M4 receptor (EC50=11 nM) agonist.
| Molecular Weight | 415.74 |
| Formula | C18H21Cl3N4O |
| CAS Number | 2250025-93-3 |
| Solubility (25°C) | DMSO 150 mg/mL Water 90 mg/mL |
| Storage | 2-8°C, sealed |
[1] Gerald Thiel, et al. Pharmacological inhibition of TRPM8-induced gene transcription
[2] G Schaber, et al. Isolation and identification of clozapine metabolites in patient urine
[3] J G Dain, et al. Biotransformation of clozapine in humans
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