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Galanthamine

Cat. No. M14548
Galanthamine Structure
Synonym:

Galantamine

Size Price Availability Quantity
20mg USD 60  USD60 In stock
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Quality Control & Documentation
Biological Activity

Galanthamine is a potent acetylcholinesterase (AChE) inhibitor with an IC50 of 500 nM.

Chemical Information
Molecular Weight 287.35
CAS Number 357-70-0
Solubility (25°C) DMSO ≥ 59 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Dimitri A Cozanitis. The snowdrop, wellspring of galanthamine : A brief descriptive and scientific history

[2] M D Fraser, et al. Integrating Narcissus-derived galanthamine production into traditional upland farming systems

[3] Luis Marco, et al. Galanthamine, a natural product for the treatment of Alzheimer's disease

[4] B Fulton, et al. Galanthamine

[5] D A Cozanitis, et al. Galanthamine

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Keywords: Galanthamine, Galantamine supplier, AChR/AChE, inhibitors, activators


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