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Racanisodamine

Cat. No. M21560
Racanisodamine Structure
Synonym:

7β-Hydroxyhyoscyamine

Size Price Availability Quantity
100mg USD 50  USD50 In stock
500mg USD 100  USD100 In stock
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Quality Control & Documentation
Biological Activity

Racanisodamine (7 beta Hydroxyhyoscyamine) is a racemic substance with similar pharmacological effects. Racanisodamine is a vasoactive Chinese herbal extract used to study acute disseminated intravascular coagulation in patients with bacterial shock.

Chemical Information
Molecular Weight 305.37
Formula C17H23NO4
CAS Number 17659-49-3
Form Solid
Solubility (25°C) DMSO ≥ 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Xian Lin, et al. Ann Palliat Med. The clinical efficacy and safety of atropine combined with omeprazole in the treatment of patients with acute gastritis: a systematic review and meta-analysis

[2] Yuetian Yu, et al. Crit Care. Effectiveness of anisodamine for the treatment of critically ill patients with septic shock: a multicentre randomized controlled trial

[3] W T Han, et al. Zhonghua Yi Xue Za Zhi. [Combination with different anticholinergic eyedrops for the treatment of children myopia]

[4] Lijuan Ma, et al. Toxins (Basel). Important poisonous plants in tibetan ethnomedicine

[5] Zhi Chen, et al. Optom Vis Sci. Effects of 0.05% racanisodamine on pupil size and accommodation

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Keywords: Racanisodamine, 7β-Hydroxyhyoscyamine supplier, AChR/AChE, inhibitors, activators


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