| Cat.No. | Name | Information |
|---|---|---|
| M2489 | Carbachol chloride | Carbachol is a cholinomimetic compound that binds and activates the acetylcholine receptor. |
| M3470 | Oxybutynin | Oxybutynin is an anticholinergic medication used to relieve urinary and bladder difficulties. |
| M3190 | PNU-282987 | PNU-282987 is a highly selective α7 nAChR agonist with Ki of 27 nM. |
| M5683 | Glycopyrrolate | Glycopyrrolate(Glycopyrronium Br) is a muscarinic competitive antagonist used as an antispasmodic. |
| M5046 | Imidafenacin (ONO-8025) | Imidafenacin (ONO-8025) is a urinary antispasmodic of the anticholinergic class.Imidafenacin(KRP-197; ONO-8025) is a potent and selective inhibitor of M3 receptors with Kb of 0.317 nM; less potent for M2 receptors (IC50=4.13 nM). |
| M4969 | Atracurium besylate | Atracurium Besylate is a neuromuscular blocking agent with ED95 of 0.2 mg/kg. Atracurium besylate also is an AChR receptor antagonist. Atracurium besylate induces bronchoconstriction and neuromuscular blockade. |
| M4788 | Scopoletin | Scopoletin is an acetylcholinesterase (AChE) inhibitor. |
| M4785 | Pteryxin | Pteryxin, coumarin in the leaves of Pteryxin, has anti-obesity effect. Pteryxin is an effective butyrylcholinesterase (BChE) inhibitor with IC50 value of 12.96 μg/ mL |
| M4736 | Nodakenin | Nodakenin is the main coumarin in the root of Peucedanum Decursivum Maxim. Nodakenin inhibited acetylcholinesterase (AChE) activity with IC50 of 84.7 μM. |
| M4697 | (+)-Corynoline | Corynoline is a reversible and non-competitive acetylcholinesterase (AChE) inhibitor with an IC50 of 30.6 μM. Corynoline acts as an anti-inflammatory by activating Nrf2. |
| M4594 | Cytisine | Cytisinicline (Cytisine) is an alkaloid that can be extracted from Laburnum and Cytisus. Cytisinicline (Cytisine) is a partial agonist of α4β2 nicotinic acetylcholinergic receptors (α4β2 nAChRs), and also a partial agonist of α4β2 and α7 receptors. It has been used medically to help people quit smoking. |
| M4590 | Buddleoside | Buddleoside |
| M4532 | Rhodionin | Rhodionin was isolated from the roots of Rhodiola crenulata and is a specific non-competitive cytochrome P450 2D6 inhibitor with IC50 of 0.761 μM and Ki of 0.769 μM. Rhodionin effectively inhibited acetylcholinesterase (AChE) in a dose-dependent manner with an IC50 range of 57.50 to 2.43 μg/mL. Rhodionin had effective DPPH radical scavenging activity with IC50 of 19.49 μM. |
| M4520 | (+)-Corydaline | Corydaline ((+) -corydaline) is an isoquinoline alkaloid extracted from Corydalis Yanhusuo. It is an inhibitor of AChE with IC50 of 226 µM. Corydaline is a μ-opioid receptor agonist (Ki = 1.23 µM) that inhibits the replication of enterovirus 71 (EV71) (IC50 = 25.23 µM). Corydaline has anti-angiogenesis, anti-allergy, gastric emptying and anti-nociception effects. |
| M4457 | Jatrorrhizine chloride | Jatrorrhizine chloride is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE. |
| M4402 | Epiberberine | Epiberberine is a potent AChE and BChE inhibitor, and a non-competitive BACE1 inhibitor, with IC50s of 1.07, 6.03 and 8.55 μM, respectively. Epiberberine is also a potent inhibitor against both ureases with IC50 values of 3.0±0.01μM for HPU (ureases from Helicobacter pylori) and 2.3±0.01μM for JBU (ureases from jack bean). |
| M4391 | Isoimperatorin | Isoimperatorin is a methanol extract from the root of Angelica dahurica. It effectively inhibits acetylcholinesterase (AChE) with IC50 of 74.6 μM. |
| M4371 | N-Methylcytisine | N-methylcytisine (Caulophylline) is a tricyclic quinoline alkaloid with hypoglycemic, pain-relieving and anti-inflammatory activities. N-methylcytisine is a selective ligand of the acetylcholine acetylcholine receptor in the central nervous system and has a high affinity for the acetylcholine acetylcholine receptor in the optic ganglion of squid (Kd: 50 nM). |
| M4287 | Picfeltarraenin-IB | Picfeltarraenin IB is a triterpenoid compound that can be extracted from Picriafel-terrae Lour (P.fel-terrae). Picfeltarraenin IB is an inhibitor of acetylcholinesterase (AChE). Picfeltarraenin IB can be used to study infection, cancer and inflammation. |
| M4217 | Timosaponin-A3 | Timosaponin AIII could inhibit the activity of acetylcholinesterase (AChE) with IC50 value of 35.4 μM. |
| M4188 | Tenuifolin | Tenuifolin |
| M3893 | TBPB | TBPB is a novel highly selective agonist for the M(1) receptor with no agonist activity at any of the other mAChR subtypes. |
| M3650 | Meclofenoxate hydrochloride | Meclofenoxate hydrochloride is an ester of dimethylethanolamine (DMAE) and 4-chlorophenoxyacetic acid (pCPA). |
| M3606 | Neostigmine Bromide | Neostigmine Bromide is a reversible acetylcholinesterase inhibitor. |
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