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Diphenidol HCl

Cat. No. M5584
Diphenidol HCl Structure
Synonym:

Difenidol hydrochloride

Size Price Availability Quantity
50mg USD 72  USD80 In stock
100mg USD 108  USD120 In stock
200mg USD 162  USD180 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Diphenidol HCl is a potent antagonist of muscarinic M2 and M3 receptor with pKb of 6.72 and 7.02, respectively, used in the treatment of vomiting and vertigo.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 345.91
Formula C21H28ClNO
CAS Number 3254-89-5
Purity >98%
Solubility 60 mg/mL in DMSO
Storage at -20°C
References

High frequency transcutaneous electrical nerve stimulation with diphenidol administration results in an additive antiallodynic effect in rats following chronic constriction injury.
Lin HT, et al. Neurosci Lett. 2015 Mar 4;589:62-6. PMID: 25596445.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Diphenidol HCl, Difenidol hydrochloride supplier, AChR/AChE, inhibitors

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