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Galanthamine HBr

Cat. No. M5672
Galanthamine HBr Structure
Synonym:

Galantamine hydrobromide

Size Price Availability Quantity
100mg USD 58.5  USD65 In stock
500mg USD 216  USD240 In stock
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Quality Control
Biological Activity

Galanthamine is an AChE inhibitor with IC50 of 0.35 μM, exhibits 50-fold selectivity against butyryl-cholinesterase.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 368.27
Formula C17H21NO3.HBr
CAS Number 1953-04-4
Purity 99.56%
Solubility 32 mg/mL in water
Storage at -20°C
References

Development of a novel high-concentration galantamine formulation suitable for intranasal delivery.
Leonard AK, et al. J Pharm Sci. 2005 Aug;94(8):1736-46. PMID: 15986464.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Galanthamine HBr, Galantamine hydrobromide supplier, AChR/AChE, inhibitors

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