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Donepezil hydrochloride

Cat. No. M3601
Donepezil hydrochloride Structure
Synonym:

E2020

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mg USD 27  USD30 In stock
50mg USD 54  USD60 In stock
100mg USD 81  USD90 In stock
200mg USD 126  USD140 In stock
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Quality Control
Biological Activity

Donepezil hydrochloride is a centrally acting reversible acetylcholinesterase inhibitor (AChEI) with an IC50 of 12.3 nM. Its main therapeutic use is in the treatment of Alzheimer’s disease where it is used to increase levels of cortical acetylcholine. It has an oral bioavailability of 100% and easily crosses the blood-brain barrier.

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Lister Hooded rats
Formulation 0.9% w:v NaCl (saline)
Dosages 18 μM/kg
Administration Administered via i.p. or p.o.
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 416
Formula C24H29NO3.HCl
CAS Number 120011-70-3
Purity >99%
Solubility Water 25 mg/mL
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Donepezil hydrochloride, E2020 supplier, AChR/AChE, inhibitors

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