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Necrostatin-1

Cat. No. M2315
Necrostatin-1 Structure
Synonym:

Nec-1

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
5mg USD 40.5  USD45 In stock
10mg USD 54  USD60 In stock
50mg USD 148.5  USD165 In stock
100mg USD 189  USD210 In stock
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Quality Control
Biological Activity

Necrostatin-1 is a specific RIP1 inhibitor and inhibits TNF-α-induced necroptosis with EC50 of 490 nM. Necrostatin-1 is also an IDO inhibitor. Necrostatin-1 (Nec-1) efficiently inhibits the TNFα-induced necrotic death of L929 cells, which does not require exogenous caspase inhibitors. Necrostatin-1 (Nec-1) prevents radiocontrast media (RCM)-induced dilation of peritubular capillaries, suggesting a novel role unrelated to cell death for the RIP1 kinase domain in the regulation of microvascular hemodynamics and pathophysiology of contrast-induced AKI (CIAKI).

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 259.33
Formula C13H13N3OS
CAS Number 4311-88-0
Purity 99.62%
Solubility DMSO 39 mg/mL
Storage at -20°C
References

hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis.
Audrey Xavier, et al. Cell Rep. 2020 May 19;31(7):107667. PMID: 32433976.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Necrostatin-1, Nec-1 supplier, RIPK, inhibitors

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