All AbMole products are for research use only, cannot be used for human consumption.
Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO.
Toxicol Appl Pharmacol. 2024 Jan;116825.
Anti-NOTCH1 therapy with OMP-52 M51 inhibits salivary adenoid cystic carcinoma by depressing epithelial-mesenchymal transition (EMT) process and inducing …
Necrostatin-1 purchased from AbMole
J Anim Sci. 2024 Sep 27.
Selenium deficiency modulates necroptosis-mediated intestinal inflammation in broiler through the lncRNAWSF27/miRNA1696/GPX3 axis
Necrostatin-1 purchased from AbMole
Cancer Res. 2023 Jan 18;83(2):251-263.
MEX3A mediates p53 degradation to suppress ferroptosis and facilitate ovarian cancer tumorigenesis
Necrostatin-1 purchased from AbMole
J Cell Physiol. 2023 Jun 3.
miR-210/NF-κB axis: A new direction for regulating cadmium-induced pig artery inflammatory injury
Necrostatin-1 purchased from AbMole
Cell Rep. 2020 May 19;31(7):107667.
hGBP1 Coordinates Chlamydia Restriction and Inflammasome Activation through Sequential GTP Hydrolysis
Necrostatin-1 purchased from AbMole
Anat Rec (Hoboken). 2020 Jan 21.
Resibufogenin inhibited colorectal cancer cell growth and tumorigenesis through triggering ferroptosis and ROS production mediated by GPX4 inactivation
Necrostatin-1 purchased from AbMole
| Molecular Weight | 259.33 |
| Formula | C13H13N3OS |
| CAS Number | 4311-88-0 |
| Solubility (25°C) | DMSO 39 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related RIPK Products |
|---|
| RIP1/RIP3/MLKL activator 1
RIP1/RIP3/MLKL activator 1 is a potent, blood-brain barrier permeable anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. |
| Oditrasertib
Oditrasertib is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 value lower than 100 nM. |
| OD36 hydrochloride
OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. |
| RIPK1-IN-12
RIPK1-IN-12 is a potent RIPK1 inhibitor. |
| DNL747
DNL747 is an ASK1 and RIPK1 inhibitor for studies related to Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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