Certificate of Analysis

 

Product Name: Necrostatin-1
Catalog Number: M2315
CAS Number: 4311-88-0

Physical and Chemical Properties
Formula: C13H13N3OS
Molecular Weight: 259.33
Solubility: DMSO 39 mg/mL
Storage: Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Chemical Structure: Necrostatin-1 Structure
Analytical Data
QC Standard: 99.62%
H-NMR: Consistent with structure
Product Information
Description: Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO.
   
Stability and Solubility Advice: Information concerning product stability, particularly in solution, has rarely been reported and in most cases we can only offer a general guide.
We recommend that stock solutions, once prepared, are stored aliquoted in tightly sealed vials and used within 1 month. Avoid repeated freeze and thaw cycles. Storage conditions for some special products should refer to their storage details.