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RIPK Receptor interacting protein kinase

Inhibitors

Cat.No.  Name Information
M2315 Necrostatin-1 Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO.
M11315 PK68 PK68 is a highly selective Type II INHIBITOR of RIPK1-dependent necroptosis with an IC50 value of approximately 90 nM. PK68 can effectively improve TNF - induced systemic inflammatory response syndrome, which has great potential in the study of inflammatory diseases and cancer metastasis.
M11187 Eclitasertib Eclitasertib (DNL-758) is a receptor interaction protein kinase 1 (RIPK1) inhibitor.IC50 The value is <1 μΜ (from patent WO2017136727A2, example 42).
M10602 Necrostatin 2 racemate Necrostatin-2 racemate (also known as 7-Cl-O-Nec-1 and Nec-1s) is a potent and specific receptor-interacting protein kinase 1 (RIPK1) inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases.
M10287 GSK547 GSK547 is a potent and highly selective receptor-interacting serine/threonine protein kinase 1 (RIPK1) inhibitor.
M9637 RIPA-56 RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.
M9625 GSK2982772 GSK2982772 is a potent, selective receptor interacting protein kinase 1 (RIPK1) inhibitor with IC50 values of 16 nM and 20 nM against human and monkey RIP1, respectively.
M9426 GSK2983559 free acid GSK2983559 free acid is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor.
M9258 HS-1371 HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM.
M9074 GSK872 GSK872 is a receptor interacting protein kinase-3 (RIP3) inhibitor, which inhibits kinase activity with an IC50 of 1.3 nM.
M8951 WEHI-345 WEHI-345 is a potent and selective RIPK2 inhibitor with IC50 of 0.13 μM.
M5232 GSK583 GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.
M5209 GSK481 GSK481 is a highly effective, selective and specific RIPK1 inhibitor with an IC50 value of 1.3 nM, which can inhibit the phosphorylation of Ser166 in wild-type human RIPK1 (IC50 value of 2.8 nM). The IC50 value of GSK481 against U937 cells was 10 nM.
M2315 Necrostatin-1 Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO.



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