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RIPK Receptor interacting protein kinase

Inhibitors

Cat.No.  Name Information
M2315 Necrostatin-1 Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO.
M13556 Necrostatin 2 Necrostatin 2 is a potent necroptosis inhibitor. EC50 for inhibition of necroptosis in FADD-deficient Jurkat T cells treated with TNF-α is 0.05 μM. Necrostatin 2 is also a RIPK1 inhibitor.
M13555 GSK-872 hydrochloride GSK-872 hydrochloride is a RIPK3 inhibitor, which binds RIP3 kinase domain with an IC50 of 1.8 nM, and inhibits kinase activity with an IC50 of 1.3 nM.
M13405 RIPK3-IN-1 RIPK3-IN-1 is a RIPK3 TYPE II DFG-out inhibitor with IC50 of 9.1 nM. RIPK3-IN-1 inhibited ABL, BRAF/V599E, MAP4K3 and SRC with IC50 values of 0.37, 0.15, 0.012 and 0.075 μM, respectively.
M13403 GSK840 GSK840 is a receptor-interacting protein kinase 3(RIP3orRIPK3) inhibitor that binds to the RIP3 kinase domain with high affinity and inhibits kinase activity with an IC50 value of 0.9nM and an IC50 value of 0.3nM.
M13394 GSK2593074A GSK2593074A is a necroptosis inhibitor that inhibits RIP1 and 3.
M11315 PK68 PK68 is a highly selective Type II INHIBITOR of RIPK1-dependent necroptosis with an IC50 value of approximately 90 nM. PK68 can effectively improve TNF - induced systemic inflammatory response syndrome, which has great potential in the study of inflammatory diseases and cancer metastasis.
M11187 Eclitasertib Eclitasertib (DNL-758) is a receptor interaction protein kinase 1 (RIPK1) inhibitor.IC50 The value is <1 μΜ (from patent WO2017136727A2, example 42).
M10602 Necrostatin 2 racemate Necrostatin-2 racemate (also known as 7-Cl-O-Nec-1 and Nec-1s) is a potent and specific receptor-interacting protein kinase 1 (RIPK1) inhibitor lacking the IDO-targeting effect, with >1000-fold more selective for RIPK1 than for any other kinase out of 485 human kinases.
M10287 GSK547 GSK547 is a potent and highly selective receptor-interacting serine/threonine protein kinase 1 (RIPK1) inhibitor.
M9637 RIPA-56 RIPA-56 is a highly potent, selective, and metabolically stable inhibitor of receptor-interacting protein 1 (RIP1) with an IC50 of 13 nM.
M9625 GSK2982772 GSK2982772 is a potent, selective receptor interacting protein kinase 1 (RIPK1) inhibitor with IC50 values of 16 nM and 20 nM against human and monkey RIP1, respectively.
M9426 GSK2983559 free acid GSK2983559 free acid is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor.
M9258 HS-1371 HS-1371 is a potent RIP3 kinase inhibitor with an IC50 of 20.8 nM.
M9074 GSK872 GSK872 is a receptor interacting protein kinase-3 (RIP3) inhibitor, which inhibits kinase activity with an IC50 of 1.3 nM.
M8951 WEHI-345 WEHI-345 is a potent and selective RIPK2 inhibitor with IC50 of 0.13 μM.
M5232 GSK583 GSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.
M5209 GSK481 GSK481 is a highly effective, selective and specific RIPK1 inhibitor with an IC50 value of 1.3 nM, which can inhibit the phosphorylation of Ser166 in wild-type human RIPK1 (IC50 value of 2.8 nM). The IC50 value of GSK481 against U937 cells was 10 nM.
M2315 Necrostatin-1 Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO.



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