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HS-1371 inhibits ATP binding to prevent RIP3 enzymatic activity. HS-1371 shows an inhibitory effect on S227 auto-phosphorylation of RIP3 at the basal level. Inhibition of RIP3 kinase activity by HS-1371 blocks necrosome complex formation, showing disruption of MLKL recruitment. HS-1371 rescues cells from TNF-induced necroptosis.
| Molecular Weight | 384.47 |
| Formula | C24H24N4O |
| CAS Number | 2158197-70-5 |
| Solubility (25°C) | DMSO: ≥ 12 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Park HH, et al. Exp Mol Med. HS-1371, a novel kinase inhibitor of RIP3-mediated necroptosis.
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