| Cat.No. | Name | Information |
|---|---|---|
| M2315 | Necrostatin-1 | Necrostatin-1 (NEC-1) is a potent inhibitor of necroptosis, with an EC50 of 490 nM in Jurkat cells. Necrostin-1 is the first identified RIPK1 inhibitor, EC50=182 nM, that reduces inflammation and inhibits colitis associated tumorigenesis. Necrostatin-1 (Nec-1) is also an inhibitor of IDO. |
| M8951 | WEHI-345 | WEHI-345 is a potent and selective RIPK2 inhibitor with IC50 of 0.13 μM. WEHI-345 delays RIPK2 ubiquitylation and NF-κB activation on oligomerization domain (NOD) stimulation. |
| M9074 | GSK872 | GSK872 is a receptor interacting protein kinase-3 (RIP3) inhibitor, which inhibits kinase activity with an IC50 of 1.3 nM. |
| M55905 | Oditrasertib | Oditrasertib is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 value lower than 100 nM. |
| M55904 | OD36 hydrochloride | OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. |
| M53369 | RIPK1-IN-12 | RIPK1-IN-12 is a potent RIPK1 inhibitor. |
| M49927 | DNL747 | DNL747 is an ASK1 and RIPK1 inhibitor for studies related to Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis. |
| M49926 | DNL104 | DNL104 is a RIPK1 inhibitor that can be used in Alzheimer's disease related studies. |
| M49391 | mRNA-0184 | mRNA-0184 is a relaxin mimetic and also a relaxin receptor-1 (RXFP1) agonist. |
| M49389 | TX-000045 | TX-000045 is an Fc-relaxin fusion protein and a potential best-in-class (BIC) RXFP1 agonist. |
| M49365 | RI-962 | RI-962 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 value of 35.0 nM.RI-962 can be used in studies related to neurological disorders and inflammatory diseases. |
| M49364 | LY3871801 | LY3871801 is a RIPK1 inhibitor for studies related to rheumatoid arthritis. |
| M49363 | DNL788 | DNL788 is a central nervous system (CNS) permeable RIPK1 small molecule inhibitor with the potential to cross the blood-brain barrier for studies related to multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). |
| M49362 | ABBV-668 | ABBV-668 is a RIPK1 inhibitor that regulates inflammation by inhibiting RIPK1 and inflammatory cytokine production. It can be used in studies related to immune system diseases. |
| M49361 | Cpd10 | Cpd10 is a type II RIPK1 inhibitor that binds to the ATP site in the inactive conformation of the kinase. |
| M49360 | Cpd 8 | Cpd 8 is a type II RIPK1 inhibitor that binds to the ATP site in the inactive conformation of the kinase. |
| M49359 | Cpd 27 | Cpd 27 is a type II RIPK1 inhibitor that binds to the ATP site in the inactive conformation of the kinase. |
| M49358 | Cpd 22b | Cpd 22b is a type II RIPK1 inhibitor that binds to the ATP site in the inactive conformation of the kinase. |
| M49357 | Cpd 71 | Cpd 71 is a type I RIPK1 inhibitor that binds to the ATP site in the active conformation of the kinase. |
| M42812 | CS640 | CS640 is a selective inhibitor of calmodulin-dependent kinases. CS640 inhibits CaMK1D, CaMK1B, CaMK1A, CaMK1G, PIP5K1C, MEK5, RIPK4 and MLK3 with IC50 values of 0.08, 0.03, 0.001, 0.001, 11.2, 0.025, 5.69 and 2.75 μM, respectively. |
| M41369 | RIPK2-IN-3 | RIPK2-IN-3 (FCG806791773) is a RIPK2 inhibitor. |
| M41368 | RIP1 kinase inhibitor 4 | RIP1 kinase inhibitor 4 is a potent RIP1K inhibitor with an EC50 value of ≤ 1000 nM. |
| M41367 | SZM-1209 | SZM-1209 is an orally effective and specific type II RIPK1 inhibitor that binds to the ATP site in the inactive conformation of the kinase with a Kd of 85 nM. |
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