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GSK2983559 free acid is a potent, specific and oral bioavailable receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells. GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse.
| Molecular Weight | 538.53 |
| Formula | C21H23N4O7PS2 |
| CAS Number | 1579965-12-0 |
| Solubility (25°C) | DMSO ≥ 3 mg/mL (Need ultrasonic and heat to 60°C) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related RIPK Products |
|---|
| RIP1/RIP3/MLKL activator 1
RIP1/RIP3/MLKL activator 1 is a potent, blood-brain barrier permeable anti-glioma agent. RIP1/RIP3/MLKL activator 1 induces necroptosis through RIP1/RIP3/MLKL pathway. |
| Oditrasertib
Oditrasertib is a receptor-interacting protein kinase 1 (RIPK1) inhibitor with an IC50 value lower than 100 nM. |
| OD36 hydrochloride
OD36hydrochloride is a RIPK2 inhibitor with an IC50 of 5.3 nM. |
| RIPK1-IN-12
RIPK1-IN-12 is a potent RIPK1 inhibitor. |
| DNL747
DNL747 is an ASK1 and RIPK1 inhibitor for studies related to Alzheimer's disease, amyotrophic lateral sclerosis, and multiple sclerosis. |
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Products are for research use only. Not for human use. We do not sell to patients.
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