All AbMole products are for research use only, cannot be used for human consumption.
Formestane (Lentaron (R)) is a second generation selective aromatase inhibitor with an IC50 of 80 nM. Formestane (Lentaron (R)) is used in the treatment of estrogen-receptor positive breast cancer in post-menopausal women. Formestane (Lentaron (R)) is often used to suppress estrogen production from anabolic steroids or prohormones. Formestane (Lentaron (R)) also acts as a prohormone to 4-hydroxytestosterone, an active steroid which displays weak androgenic activity in addition to acting as a mild aromatase inhibitor. Formestane has poor oral bioavailability and as such is no longer popular as many orally active aromatase inhibitors have been identified. Cells were treated with different aromatase inhibitors anastrozole, formestane, exemestane, and letrozole, or antiestrogens tamoxifen and fulvestrant. UMB-1Ca cells showed significant growth inhibition in response to fulvestrant (100 nM, P < 0.0005) and partial growth inhibition in response to letrozole (100 nM, P < 0.005).
Plant J. 2022 Jun;110(6):1636-1650.
Small molecule RHP1 promotes root hair tip growth by acting upstream of the RHD6-RSL4-dependent transcriptional pathway and ROP signaling in plants
Formestane purchased from AbMole
| Molecular Weight | 302.41 |
| Formula | C19H26O3 |
| CAS Number | 566-48-3 |
| Solubility (25°C) | DMSO 55 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Rajeev Kharb, et al. Aromatase inhibitors: Role in postmenopausal breast cancer
[3] Xavier de la Torre, et al. Detection of formestane abuse by mass spectrometric techniques
| Related Products |
|---|
| PCL-PEG-MAL
PCL-PEG-MAL is an amphiphilic block copolymer consisting of polycaprolactone (PCL), polyethylene glycol (PEG) and maleimide (MAL) functional groups. PCL-PEG-MAL is used in targeted delivery systems, surface modification of nanomaterials, functionalisation of biomaterials and biosensing technologies for specific chemical linkages or biomolecular immobilisation. |
| DSPE-PEG-Streptavidin
DSPE-PEG-Streptavidin is an important biocoupling molecule widely used in biomedical research, especially in drug delivery, targeted therapies, immunodiagnostics and biosensors. Through the specific binding between streptavidin and biotin, DSPE-PEG-Streptavidin can help to achieve efficient loading and targeted action in targeted delivery systems. In addition, the molecule is widely used in molecular imaging and bioassays, especially for molecular recognition using the strong affinity between streptavidin and biotin in assay platforms that require high sensitivity and specificity. |
| E7107
E7107 is a first-in-class precursor messenger ribonucleic acid (pre-mRNA) spliceosome inhibitor. |
| KL044
KL044 is a stabilizer of the clock protein cryptochrome (CRY). KL044 is a potent chemical probe with a pEC50 value of 7.32, leading to the extension of the circadian period and repression of Per2 activity. |
| 2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide
2-(2-Methylphenoxy)-4H-1,3,2-benzodioxaphosphorin 2-oxide is a biochemical material that can be used in scientific research. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
