Gastrin-I (human) is the endogenous peptide produced in the stomach, which increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. Gastrin-I (1.5, 5, 15 and 45 nmol/kg, i.v.) increases pepsinogen and acid secretion in rats.
|Solubility (25°C)||Water 10 mM|
|Storage||-20°C, protect from light|
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related Cholecystokinin Receptor Products|
PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB.
|[Leu15]-Gastrin I (human)
[Leu15]-Gastrin I (human) is a peptide that acts via cholecystokinin (CCK) or CCK-B receptor (CCK-BR).
|Gastrin I (rat) TFA
Gastrin I (rat) TFA is a peptide hormone, which can stimulate gastric acid secretion potently.
|Mini Gastrin I, human TFA
Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.
|Mini Gastrin I, human
Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.
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