Gastrin-I (human) is the endogenous peptide produced in the stomach, which increases gastric acid secretion via cholecystokinin 2 (CCK2) receptor. Gastrin-I (1.5, 5, 15 and 45 nmol/kg, i.v.) increases pepsinogen and acid secretion in rats.
| Molecular Weight | 2098.20 |
| Formula | C97H124N20O31S |
| CAS Number | 10047-33-3 |
| Solubility (25°C) | Water 10 mM |
| Storage | -20°C, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Related Cholecystokinin Receptor Products |
|---|
| PD 135158
PD 135158 (CAM 1028) is a selective CCKB receptor antagonist with an IC50 of 2.8 nM against mouse cortex CCKB. |
| [Leu15]-Gastrin I (human)
[Leu15]-Gastrin I (human) is a peptide that acts via cholecystokinin (CCK) or CCK-B receptor (CCK-BR). |
| Gastrin I (rat) TFA
Gastrin I (rat) TFA is a peptide hormone, which can stimulate gastric acid secretion potently. |
| Mini Gastrin I, human TFA
Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide. |
| Mini Gastrin I, human
Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide. |
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