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Proglumide sodium salt is a non-selective, orally active cholecystokinin (CCK) antagonist. Proglumide sodium inhibits CCK-stimulated amylase secretion and prevents CCK-induced 2-deoxyglucose uptake in mouse pancreatic acini. Proglumide sodium blocks growth of HT29 colon carcinoma cells in response to gastrin 17 treatment.
| Molecular Weight | 356.39 |
| Formula | C18H25N2NaO4 |
| CAS Number | 99247-33-3 |
| Solubility (25°C) | Water 35.64 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Cholecystokinin Receptor Products |
|---|
| CI-988
CI-988 (PD134308) is a potent, selective and orally active CCK2R (cholecystokinin 2 receptor) antagonist with an IC50 of 1.7 nM for mouse cortex CCK2. |
| Itriglumide
Itriglumide (CR 2945) is an anthranilic acid derivative. |
| Sincalide
Sincalide (Cholecystokinin octapeptide, CCK‐8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. |
| Gastrin I, rat
Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently. |
| Tetragastrin
Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. |
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Products are for research use only. Not for human use. We do not sell to patients.
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