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Pentagastrin (ICI-50123) is a synthetic polypeptide that has effects like gastrin when given parenterally. It stimulates the secretion of gastric acid, pepsin, and intrinsic factor and has been used as a diagnostic aid as the pentagastrin-stimulated calcitonin test. Pentagastrin binds to the cholecystokinin-B receptor, which is expressed widely in the brain. Activation of these receptors activates the phospholipase C second messenger system. When given intravenously it causes panic attacks.
| Molecular Weight | 767.89 |
| Formula | C37H49N7O9S |
| CAS Number | 5534-95-2 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
[1] Diana Radu, et al. Pentagastrin test for anxiety--psychophysiology and personality
[2] A S de Leeuw, et al. Pentagastrin has panic-inducing properties in obsessive compulsive disorder
[3] R M Wexler, et al. Pentagastrin in diffuse oesophageal spasm
| Related Cholecystokinin Receptor Products |
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| CI-988
CI-988 (PD134308) is a potent, selective and orally active CCK2R (cholecystokinin 2 receptor) antagonist with an IC50 of 1.7 nM for mouse cortex CCK2. |
| Itriglumide
Itriglumide (CR 2945) is an anthranilic acid derivative. |
| Sincalide
Sincalide (Cholecystokinin octapeptide, CCK‐8) is a rapid-acting amino acid polypeptide hormone analogue of cholecystokinin (CCK) for intravenous use in postevacuation cholecystography. |
| Gastrin I, rat
Gastrin I, rat (Rat Gastrin-17) is a peptide hormone, can stimulate gastric acid secretion potently. |
| Tetragastrin
Tetragastrin (Cholecystokinin tetrapeptide; CCK-4) is the C-terminal tetrapeptide of gastrin. |
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