All AbMole products are for research use only, cannot be used for human consumption.
Bafilomycin A1 (BafA1) is a toxic macrolide antibiotic derived from Streptomyces griseus. Bafilomycin A1 inhibits the short circuit current induced by the outer mantle epithelium (OME). The IC50 and maximum inhibition dose of Bafilomycin A1 are 0.17 μM and 0.5 μM, respectively. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.
Oxid Med Cell Longev. 2022 Jan 25;2022:8096009.
Interaction between TRPML1 and p62 in Regulating Autophagosome-Lysosome Fusion and Impeding Neuroaxonal Dystrophy in Alzheimer's Disease
Bafilomycin A1 purchased from AbMole
Transl Psychiatry. 2021 Aug 5;11(1):421.
BRUCE silencing leads to axonal dystrophy by repressing autophagosome-lysosome fusion in Alzheimer's disease
Bafilomycin A1 purchased from AbMole
Mol Immunol. 2020 Jan;117:12-19.
Toll-like receptor 4 knockout protects against diabetic-induced imbalance of bone metabolism via autophagic suppression.
Bafilomycin A1 purchased from AbMole
| Molecular Weight | 622.83 |
| Formula | C35H58O9 |
| CAS Number | 88899-55-2 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage | -20°C, protect from light, sealed |
| Related Proton Pump Products |
|---|
| Lansoprazole sulfone
Lansoprazole sulfone (AG-1813) is an orally active and selective inhibitor of H+, K+-ATPase. |
| Esomeprazole-d3 sodium
Esomeprazole-d3 sodium |
| Caloxin 2A1
Caloxin 2A1 is an extracellular plasma membrane Ca2+-ATPase (PMCA) peptide inhibitor. |
| CS-526
CS-526 is a potent, selective, reversible and orally active acid pump antagonist. |
| Revaprazan
Revaprazan (SB 641257) is a reversible proton pump inhibitor with significant anti-inflammatory effects. Revaprazan can be used for chronic gastric inflammation research. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.
