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Bafilomycin A1

Cat. No. M4953
Bafilomycin A1 Structure


Size Price Availability Quantity
1mg USD 430  USD430 In stock
5mg USD 1560  USD1560 In stock
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Quality Control & Documentation
Biological Activity

Bafilomycin A1 (BafA1) is a toxic macrolide antibiotic derived from Streptomyces griseus. Bafilomycin A1 inhibits the short circuit current induced by the outer mantle epithelium (OME). The IC50 and maximum inhibition dose of Bafilomycin A1 are 0.17 μM and 0.5 μM, respectively. Bafilomycins are specific inhibitors of vacuolar-type H+-ATPase. (V-ATPase). The most used bafilomycin is bafilomycin A1. This is a useful tool as it can prevent the re-acidification of synaptic vesicles once they have undergone exocytosis.

Product Citations
Chemical Information
Molecular Weight 622.83
Formula C35H58O9
CAS Number 88899-55-2
Solubility (25°C) DMSO 10 mM
Storage -20°C, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Oliveira PF, et al. Comp Biochem Physiol A Mol Integr Physiol. H+-ATPase of crude homogenate of the outer mantle epithelium of Anodonta cygnea.

[2] al-Fifi ZI, et al. Insect Biochem Mol Biol. Characterization of ATPases of apical membrane fractions from Locusta migratoria Malpighian tubules.

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Keywords: Bafilomycin A1, Baf-A1;BafA1 supplier, Proton Pump, inhibitors, activators

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