A-83-01, an inhibitor of TGF-β type I receptor, increased the expression of Myf5 and MyoD, and enhanced myotube formation.The targeting efficacy of single intravenous injections of F-SL combined with A-83-01 was evaluated by measurement of the biodistribution and the antitumor effect in mice bearing murine lung carcinoma M109. A-83-01 temporarily changed the tumor vasculature around 3 h post injection. A-83-01 induced 1.7-fold higher compound accumulation of F-SL in the tumor than liposome alone at 24 h post injection.
*The compound is unstable in solutions, freshly prepared is recommended
Adv Sci (Weinh). 2023 Jul 23;e2302640.
Micro-Engineered Organoid-on-a-Chip Based on Mesenchymal Stromal Cells to Predict Immunotherapy Responses of HCC Patients
A 83-01 purchased from AbMole
Cell Death Dis. 2022 Apr 5;13(4):303.
KLF5 inhibition overcomes oxaliplatin resistance in patient-derived colorectal cancer organoids by restoring apoptotic response
A 83-01 purchased from AbMole
Nat Biomed Eng. 2020 Sep;4(9):863-874.
High-throughput automated organoid culture via stem-cell aggregation in microcavity arrays
A 83-01 purchased from AbMole
 |
Source | Breast Cancer Res Treat (2017). Figure 6. A 83-01 |
| Method | MTT assay | |
| Cell Lines | SKBR3 cells | |
| Concentrations | 1 μM | |
| Incubation Time | 16 h | |
| Results | As shown in Fig. 6c that A83-01 alone reduced approximately 17% cell migration of JIMT1 and trastuzumab alone inhibited 20% cell migration, while in combination of A83-01 and trastuzumab synergistically inhibited JIMT1 cell migration up to 90%. |
| Molecular Weight | 421.52 |
| Formula | C25H19N5S |
| CAS Number | 909910-43-6 |
| Solubility (25°C) | DMSO 24 mg/mL |
| Storage | -20°C, protect from light, dry, sealed |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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