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AZ12601011

Cat. No. M14943

All AbMole products are for research use only, cannot be used for human consumption.

AZ12601011 Structure

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Quality Control & Documentation
Biological Activity

AZ12601011 is an orally active, selective TGFBR1 kinase inhibitor with an IC50 of 18 nM and a Kd of 2.9 nM. AZ12601011 inhibits phosphorylation of SMAD2 via selectively inhibiting ALK4, TGFBR1, and ALK7. AZ12601011 inhibits mammary tumor growth .

Chemical Information
Molecular Weight 313.36
Solubility (25°C) DMSO 5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Xiao-Guo Suo, et al. Targeted inhibition of TGF-β type I receptor by AZ12601011 protects against kidney fibrosis

[2] J H S Dayal, et al. Heterogeneous addiction to transforming growth factor-beta signalling in recessive dystrophic epidermolysis bullosa-associated cutaneous squamous cell carcinoma

[3] Lindsay C Spender, et al. Preclinical Evaluation of AZ12601011 and AZ12799734, Inhibitors of Transforming Growth Factor β Superfamily Type 1 Receptors

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  Catalog
Abmole Inhibitor Catalog




Keywords: AZ12601011 supplier, TGF-β Receptor, inhibitors, activators

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