Free shipping on all orders over $ 500

SB 202190

Cat. No. M2062
SB 202190 Structure


Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 30  USD30 In stock
5mg USD 20  USD20 In stock
10mg USD 30  USD30 In stock
25mg USD 50  USD50 In stock
50mg USD 65  USD65 In stock
100mg USD 100  USD100 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

SB 202190 is a potent p38 MAPK inhibitor. SB 202190 binds within the ATP pocket of the active kinase (Kd = 38 nM, as measured in recombinant human p38), and selectively inhibits the p38α and β isoforms (IC50 = 50 and 100 nM at SAPK2a/p38 and SAPK2b/p38β2 respectively). SB 202190 by itself was sufficient to induce cell death, with typical apoptotic features such as nucleus condensation and intranucleosomal DNA fragmentation. SB 202190 stimulated the activity of CPP32-like caspases, and its apoptotic effect was completely blocked by the expression of bcl-2. When tested at 10 μM, SB 202190 has negligible effects on a range of other kinases, including other MAP kinases (ERKs, JNKs). Recently, SB 202190 has been used to elucidate the roles of p38 MAP kinases in inflammatory cytokine expression, nicotine-induced receptor expression, and HIV-mediated depressive disorder.

Product Citations
Customer Product Validations & Biological Datas
Source Br J Pharmacol (2006). Figure 1. SB 202190
Method FLIPR
Cell Lines HEK293 cells
Concentrations 10 μM
Incubation Time 18 h
Results The MAPK inhibitor, SB-202190, also antagonized human P2X7 receptor-mediated responses but was generally less potent than SB-203580 with pIC50 values varying from 6.2 to 4.8, depending on BzATP concentration.
Chemical Information
Molecular Weight 331.34
Formula C20H14FN3O
CAS Number 152121-30-7
Solubility (25°C) DMSO 36 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Paillas S, et al. Cancer Res. Targeting the p38 MAPK pathway inhibits irinotecan resistance in colon adenocarcinoma.

[2] Muniyappa H, et al. Cell Signal. Activation of c-Jun N-terminal kinase (JNK) by widely used specific p38 MAPK inhibitors SB202190 and SB203580: a MLK-3-MKK7-dependent mechanism.

[3] Nemoto S, et al. J Biol Chem. Induction of apoptosis by SB202190 through inhibition of p38beta mitogen-activated protein kinase.

Related p38 MAPK Products

HWY336 is a selective, non-ATP competitive dual MKK4 and MKK7 inhibitor with IC50 values of 6 µM on MKK4 and 10 µM on MKK7 in vitro. HWY336 inhibits the phosphorylation of MKK4/MKK7 inside the activation loop or hinders the substrate to access the kinase.


BSJ-04-122 is a covalent MKK4/7 dual inhibitor. BSJ-04-122 inhibits MKK4 and MKK7 with IC50 values of 4 nM and 181 nM, respectively.

OVA-E1 peptide TFA

OVA-E1 peptide TFA, is an antagonist variant of SIINFEKL [OVA (257-264).

MBP MAPK Substrate

MBP MAPK Substrate is used as an exogenous substrate for MAPK.

OVA-E1 peptide

OVA-E1 peptide, is an antagonist variant of SIINFEKL [OVA (257-264).

Abmole Inhibitor Catalog

Keywords: SB 202190, SB202190 supplier, p38 MAPK, inhibitors, activators

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.