Interleukin-1β (IL-1β) is a non-secretory pro-inflammatory cytokine produced primarily by activated macrophages as well as neutrophils, epithelial cells and endothelial cells. It has metabolic, physiological, and hematopoietic activities and plays one of the central roles in the regulation of the immune response. both IL-1α and IL-1β bind to the same receptors and have similar but not identical biological properties. Mature rat IL1β shares 90% similarity with cotton mice and mice, and 65%-77% similarity with canine, human and rhesus monkey IL1β.
Measured by a cell proliferation assay using mouse D10S cells, the ED50 is < 10.0 pg/ml, corresponding to a specific activity of > 1.0 × 108 units/mg.
Accession # Q63264
Endotoxin < 0.2 EU/μg
Apparent Molecular Weight: ~17.3 kDa, reducing conditions
Lyophilized after extensive dialysis against PBS.
Mol Med Rep. 2023 Nov;28(5):202.
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Recombinant Rat IL-1β (E. coli) purchased from AbMole
| Form | Lyophilized powder |
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O up to 100 μg/ml. |
| Storage | Stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days and at -20°C for 3 months. |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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