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R-Spondin-1 (Rspo-1) belongs to the Wnt regulator (Rspo) family. Currently, the family consists of four structurally related secretory ligands (Rspo 1-4), all containing basic residues and thrombospondin structural domains. R-Spondin-1 is a secreted activator protein containing two adjacent cysteine furan domains (aa 34-135) with a potential N-glycosylation site, followed by a thrombospondin (TSP1) motif (aa 147-207) and a region rich in basic residues (aa 211-263). Rspo-1 is expressed in certain regions of the developing central nervous system, as well as the adrenal gland, ovary, testis, thyroid and trachea. Rspo can interact with the Frizzled/LRP6 receptor complex to stimulate the Wnt/β-catenin signaling pathway.
Patent. CN119639678A 2025 Mar 18.
Patent. CN119639678A
Recombinant Human R-spondin 1/RSPO1 (HEK293, His) purchased from AbMole
Patent. CN118879569A 2024 Nov 01.
Patent. CN118879569A
Recombinant Human R-spondin 1/RSPO1 (HEK293, His) purchased from AbMole
| Solubility (25°C) | Reconstitute the lyophilized powder in ddH2O or PBS to 100 μg/ml |
| Storage | Stable for up to 12 months at -20°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 6 months at -20°C. |
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