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Bulevirtide

Cat. No. M10246

All AbMole products are for research use only, cannot be used for human consumption.

Bulevirtide Structure
Synonym:

Myrcludex B

Size Price Availability Quantity
1mg USD 90  USD90 In stock
5mg USD 280  USD280 In stock
10mg USD 460  USD460 In stock
25mg USD 850  USD850 In stock
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Quality Control & Documentation
Biological Activity

Bulevirtide is a first-in-class entry inhibitor for the treatment of chronic Hepatitis D infection. Bulevirtide prevents Hepatitis D entry into cells. It is effective in the reduction of Hepatitis D virus (HDV) RNA levels and improvement of liver inflammation in cases of Hepatitis D infection. In rats, bulevirtide administered by subcutaneous injection is rapidly absorbed with a Cmax of 4 to 6 hours.

Product Citations
Chemical Information
CAS Number 2012558-47-1
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ahmed Ghallab, et al. J Hepatol. Interruption of bile acid uptake by hepatocytes after acetaminophen overdose ameliorates hepatotoxicity

[2] Lena Allweiss, et al. Gut. Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo

[3] Tassilo Volz, et al. J Hepatol. The entry inhibitor Myrcludex-B efficiently blocks intrahepatic virus spreading in humanized mice previously infected with hepatitis B virus

[4] Shirin Nkongolo, et al. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz. [Bulevirtide as the first specific agent against hepatitis D virus infections-mechanism and clinical effect]

[5] D Yardeni, et al. Drugs Today (Barc). Bulevirtide for HBV and HDV infections

[6] Connie Kang, et al. Drugs. Bulevirtide: First Approval

[7] Christopher Koh, et al. Clin Liver Dis. HBV/HDV Coinfection: A Challenge for Therapeutics

[8] Karin Wisskirchen, et al. J Clin Invest. T cell receptor grafting allows virological control of Hepatitis B virus infection

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Keywords: Bulevirtide, Myrcludex B supplier, Peptides, inhibitors, activators

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