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Bevacizumab

Cat. No. M6166
Bevacizumab Structure
Synonym:

bevacizumab;Avastin

Size Price Availability Quantity
5mg USD 660  USD660 In stock
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Quality Control & Documentation
Biological Activity

Bevacizumab is A humanized IgG1 monoclonal antibody that binds with high affinity and specificity to all VEGF-A.

Product Citations
Protocol (for reference only)
Cell Experiment
Cell lines NSCLC cell lines
Preparation method Six NSCLC cell lines were seeded (~2,000–5,000 cells per well, depending on cell type) onto 96-well plates. After 24 h of incubation, cells were treated with erlotinib (0–20 µmol/L), bevacizumab (0–20 ng/mL) or a combination of these agents (erlotinib 1 µmol/L; bevacizumab 10 ng/mL) for 72 h in serum-containing medium. The viability was determined by MTS assay (Promega, Madison, WI) according to the manufacturer’s instructions.
Concentrations 0–20 ng/mL
Incubation time 72 h
Animal Experiment
Animal models Female Wistar rats
Formulation 0.9%sodium chloride solution
Dosages 30 mg/kg
Administration i.p.
Chemical Information
CAS Number 216974-75-3
Solubility (25°C) Water
PBS
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liu W, et al. Eye Sci. Effect of Avastin on the migration and invasion of pterygium fibroblasts.

[2] Lee AL, et al. Biomacromolecules. Injectable biodegradable hydrogels from vitamin D-functionalized polycarbonates for the delivery of avastin with enhanced therapeutic efficiency against metastatic colorectal cancer.

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Keywords: Bevacizumab, bevacizumab;Avastin supplier, VEGFR/PDGFR, inhibitors, activators

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