AMPK Adenosine Monophosphate Activated Protein Kinase

Inhibitors

Cat.No.	Name	Information
M3132	WZ4003	WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases.
M2238	Dorsomorphin (Compound C) dihydrochloride	Dorsomorphin (BML-275) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM) and bone morphogenic protein (BMP) signaling.
M3946	BML-275	BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays.
M4897	AICAR	AICAR is an activator of AMP-activated protein kinase (AMPK), down-regulates the insulin receptor expression in HepG2 cells.
M21194	IM156	IM156 is a derivative of the long-used diabetic drug metformin, which appears to be active in a model of pulmonary fibrosis. It is a potent, orally active AMPK activator.
M20630	ex229 (compound 991)	EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK.
M14836	EB-3D	EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC₅₀ of 1 μM for ChoKα1.
M13811	ZLN024 hydrochloride	ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
M13810	Palmitelaidic Acid	Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
M13809	Chitosan oligosaccharide	Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
M13808	Buformin hydrochloride	Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent.
M13807	Ampkinone	Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
M13806	AICAR phosphate	AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator.
M13805	7-Methoxyisoflavone	7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).
M13407	YLF-466D	YLF-466Dis a novel AMPK activator that inhibits thrombin - induced platelet aggregation.
M13362	ASP4132	ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM and anticancer activity that promotes tumor regression in a xenograft mouse model of breast cancer.
M13361	MK8722	Mk-8722 is a potent, direct, PAN-AMPK allosteric activator.
M11462	IMM-H007	Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK).
M11324	BC1618	BC1618, an orally active Fbxo48 inhibitor, stimulates Ampk signaling (preventing activated pAmpkα from being degraded by fBXO48-mediated proteasome). BC1618 promotes mitochondrial division, autophagy and insulin sensitivity in the liver.
M11007	O-304	O-304 is a pioneering, orally active pan-AMPK activator that increases AMPK activity by inhibiting dephosphorylation of pAMPK.
M9911	IM156	IM156, a metformin derivative, is an oxidative phosphorylation inhibitor that increases AMPK phosphorylation.
M9764	MK-3903	MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM).
M8095	PF-06409577	Pf-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 subtype with an EC50 value of 7 nM.
M5336	Phenformin HCl	Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.

Signaling Pathways

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AMPK Adenosine Monophosphate Activated Protein Kinase

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