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AMPK Adenosine Monophosphate Activated Protein Kinase

Inhibitors

Cat.No.  Name Information
M3132 WZ4003 WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases.
M2238 Dorsomorphin (Compound C) dihydrochloride Dorsomorphin (BML-275) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK) (Ki = 109 nM) and bone morphogenic protein (BMP) signaling.
M3946 BML-275 BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays.
M14836 EB-3D EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1.
M13811 ZLN024 hydrochloride ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively.
M13810 Palmitelaidic Acid Palmitelaidic Acid (9-trans-Hexadecenoic acid) is the trans isomer of palmitoleic acid. Palmitoleic acid is one of the most abundant fatty acids in serum and tissue.
M13809 Chitosan oligosaccharide Chitosan oligosaccharide (COS) is an oligomer of β-(1→4)-linked D-glucosamine. Chitosan oligosaccharide (COS) activates AMPK and inhibits inflammatory signaling pathways including NF-κB and MAPK pathways.
M13808 Buformin hydrochloride Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent.
M13807 Ampkinone Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
M13806 AICAR phosphate AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator.
M13805 7-Methoxyisoflavone 7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).
M13407 YLF-466D YLF-466Dis a novel AMPK activator that inhibits thrombin - induced platelet aggregation.
M13362 ASP4132 ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM and anticancer activity that promotes tumor regression in a xenograft mouse model of breast cancer.
M13361 MK8722 Mk-8722 is a potent, direct, PAN-AMPK allosteric activator.
M11462 IMM-H007 Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK).
M11324 BC1618 BC1618, an orally active Fbxo48 inhibitor, stimulates Ampk signaling (preventing activated pAmpkα from being degraded by fBXO48-mediated proteasome). BC1618 promotes mitochondrial division, autophagy and insulin sensitivity in the liver.
M11007 O-304 O-304 is a pioneering, orally active pan-AMPK activator that increases AMPK activity by inhibiting dephosphorylation of pAMPK.
M9911 IM156 IM156, a metformin derivative, is an oxidative phosphorylation inhibitor that increases AMPK phosphorylation.
M9764 MK-3903 MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM).
M8095 PF-06409577 Pf-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 subtype with an EC50 value of 7 nM.
M5336 Phenformin HCl Phenformin HCl is a hydrochloride salt of phenformin that is an anti-diabetic drug from the biguanide class. It activates AMPK, increasing activity and phosphorylation.
M5326 HTH-01-015 HTH-01-015 is a potent and selective NUAK1 inhibitor with IC50 of 100 nM, >100-fold selectivity over NUAK2.
M5207 Bempedoic acid (ETC-1002) Bempedoic acid (ETC-1002) is a novel, first-in-class, orally available ATP-citrate lyase (ACL) inhibitor, Bempedoic acid (ETC-1002) can activate AMPK.



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