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Cat. No. M13805
7-Methoxyisoflavone Structure
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100mg USD 50  USD50 In stock
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Biological Activity

7-Methoxyisoflavone is an isoflavone derivative and also an activator of adenosine monophosphate-activated protein kinase (AMPK).

Chemical Information
Molecular Weight 252.26
CAS Number 1621-56-3
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Hao Dong, et al. Sci Rep. 7-Methoxyisoflavone ameliorates atopic dermatitis symptoms by regulating multiple signaling pathways and reducing chemokine production

[2] Michele Iannone, et al. Rapid Commun Mass Spectrom. An investigation on the metabolic pathways of synthetic isoflavones by gas chromatography coupled to high accuracy mass spectrometry

[3] Cui-Cui Qi, et al. Nat Prod Res. A new isoflavone from the roots of Ficus auriculata

[4] Yannick Lecompte, et al. J Pharm Biomed Anal. UPLC-ESI-Q-TOF-MS(E) identification of urinary metabolites of the emerging sport nutrition supplement methoxyisoflavone in human subjects

[5] Jos Gustavo L de Almeida, et al. Magn Reson Chem. NMR spectral assignments of a new [C--O--C] isoflavone dimer from Andira surinamensis

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Keywords: 7-Methoxyisoflavone supplier, AMPK, inhibitors, activators

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