Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro.
Inflamm Res. 2023 Dec 13.
The immunomodulatory effects of metformin in LPS-induced macrophages: an in vitro study
Metformin purchased from AbMole
| Molecular Weight | 129.17 |
| Formula | C4H11N5 |
| CAS Number | 657-24-9 |
| Solubility (25°C) | DMSO 60 mg/mL Water 30 mg/mL |
| Storage | -20°C, sealed, protect from light |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Ziquan Lv, et al. Metformin and Its Benefits for Various Diseases
[2] Monika Podhorecka, et al. Metformin - its potential anti-cancer and anti-aging effects
[3] Laura J McCreight, et al. Metformin and the gastrointestinal tract
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