About 4 results found for searched term "Metformin" (0.305 seconds)
| Cat.No. | Name | Target |
|---|---|---|
| M2049 | Metformin hydrochloride | Autophagy |
| 1,1-Dimethylbiguanide hydrochloride | ||
| Metformin HCl is a biguanide inhibitor that reduces blood glucose mainly by inhibiting hepatic glycogen production (hepatic gluconeogenesis), while Metformin is a CD47 inhibitor in vitro. | ||
| M3244 | Metformin | AMPK |
| 1,1-Dimethylbiguanide | ||
| Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro. | ||
| M8729 | Syrosingopine | Others |
| Syrosingopine is an antihypertensive agent related to reserpine that was found to potentiate the anticancer effects of the antidiabetic agent metformin and phenformin without harmful effects on normal cells. | ||
| M9911 | Lixumistat | Mitochondrial Related |
| IM156; HL156A | ||
| Lixumistat (IM156) is a novel biguanide mitochondrial protein complex 1 inhibitor of oxidative phosphorylation (OXPHOS) with anti-tumor activity. Lixumistat regulates OXPHOS to attenuate mitochondrial metabolic reprogramming and inhibit lung fibrosis. Lixumistat (IM156) is a metformin derivative, which increases AMPK phosphorylation. | ||
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