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BAY-3827 is a potent AMPK inhibitor which inhibits AMPK kinase activity with IC50 values of 1.4 nM at low (10 µM ATP concentration) and 15 nM at high (2 mM ATP concentration). BAY-3827 prevents phosphorylation of acetyl-CoA carboxylase 1 (ACC1). BAY-3827 (1 and 5 μM; 24 and 48 h) represses LIPE gene expression, reduces serine/threonine kinase AKT3 and blocks the expression of several genes from the mitochondrial carnitine palmitoyltransferase (CPT) family which is involved in acyl carnitine formation in VCaP cells.
| Molecular Weight | 468.53 |
| Formula | C27H25FN6O |
| CAS Number | 2377576-35-5 |
| Solubility (25°C) | DMSO 20 mg/mL (ultrasonic and warming) |
| Storage | -20°C, protect from light |
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