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BML-275

Cat. No. M3946
BML-275 Structure
Synonym:

Dorsomorphin, Compound C

Size Price Availability Quantity
5mg USD 58.5  USD65 In stock
10mg USD 85.5  USD95 In stock
50mg USD 306  USD340 In stock
100mg USD 486  USD540 In stock
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Quality Control
Biological Activity

BML-275 inhibits BMP signals required for embryogenesis and promoted significant neural differentiation from human pluripotent stem cell (hPSC) lines. BML-275 acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase); Ki = 109 nM in the presence of 5 μM ATP and the absence of AMP). BML-275 inhibited the cell proliferation of 4 human pancreatic cancer cell lines (MIA PaCa-2, Panc-1, Colo-357 and AsPC-1). In addition, BML-275 significantly increased the generation of intracellular reactive oxygen species (ROS), followed by induction of DNA damage signaling and apoptosis. Furthermore, BML-275 induced cell cycle arrest in the G2/M phase. BML-275 exerts its antitumor effects by inducing ROS generation, DNA damage and apoptosis via inhibition of the AMPK pathway and by inducing G2/M arrest via a pathway independent of AMPK, implicating its potential application as an antitumor agent for pancreatic cancer.

Product Citations
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 399.49
Formula C24H25N5O
CAS Number 866405-64-3
Purity 100.0%
Solubility DMSO 3 mg/mL warming
Storage at -20°C
References

Acetic acid activates the AMP-activated protein kinase signaling pathway to regulate lipid metabolism in bovine hepatocytes.
Li X, et al. PLoS One. 2013 Jul 4;8(7):e67880. PMID: 23861826.

BML-275, an AMPK inhibitor, induces DNA damage, G2/M arrest and apoptosis in human pancreatic cancer cells.
Duong HQ, et al. Int J Oncol. 2012 Dec;41(6):2227-36. PMID: 23076030.

Compound C induces protective autophagy in cancer cells through AMPK inhibition-independent blockade of Akt/mTOR pathway.
Vucicevic L, et al. Autophagy. 2011 Jan;7(1):40-50. PMID: 20980833.

AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.
Jin J, et al. J Lipid Res. 2009 Dec;50(12):2389-97. PMID: 19528633.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BML-275, Dorsomorphin, Compound C supplier, AMPK, inhibitors

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