| Cat.No. | Name | Information |
|---|---|---|
| M3132 | WZ4003 | WZ4003 is a highly specific NUAK kinase inhibitor with IC50 of 20 nM and 100 nM for NUAK1 and NUAK2, respectively, without significant inhibition on 139 other kinases. |
| M2238 | Dorsomorphin dihydrochloride | Dorsomorphin (BML-275; Compound C) dihydrochloride is a potent inhibitor of AMP-activated protein kinase (AMPK), with a Ki of 109 nM. Dorsomorphin dihydrochloride inhibits BMP pathway by targeting the type I receptors ALK2, ALK3, and ALK6. Dorsomorphin dihydrochloride induces autophagy. |
| M3946 | BML-275 | BML-275 (Dorsomorphin) is a cell-permeable pyrazolopyrimidine compound shown to be an AMPK inhibitor with Ki of 109 nM in cell-free assays. |
| M4897 | AICAR | AICAR is an adenosine analog and activator of AMPK that regulates glucose and lipid metabolism and inhibits the production of pro-inflammatory cytokines and iNOS. In addition, AICAR is an inhibitor of autophagy, YAP and mitophagy. |
| M8095 | PF-06409577 | Pf-06409577 is a potent and selective allosteric activator of AMPK α1β1γ1 subtype with an EC50 value of 7 nM. |
| M3244 | Metformin | Metformin (1, 1-dimethylbiguanide) inhibits mitochondrial respiratory chains in the liver, leads to AMPK activation and enhances insulin sensitivity, and can be used in type 2 diabetes research. Metformin can cross the blood-brain barrier and induce autophagy, and Metformin is a CD47 inhibitor in vitro. |
| M5207 | Bempedoic acid (ETC-1002) | Bempedoic acid (ETC-1002) is a novel, first-in-class, orally available ATP-citrate lyase (ACL) inhibitor, Bempedoic acid (ETC-1002) can activate AMPK. |
| M38948 | Kazinol U | Kazinol U inhibits melanogenesis through the inhibition of tyrosinase-related proteins via AMPK activation. |
| M38947 | 3α-Hydroxymogrol | 3α-Hydroxymogrol is a triterpenoid isolated from Siraitia grosvenorii Swingle, acts as a potent AMPK activator, and enhances AMPK phosphorylation. |
| M30689 | D942 | D942 is a cell penetrant AMPK activator and partially inhibits the mitochondrial complex I. In multiple myeloma cells, D942 inhibits cell growth. |
| M30552 | COH-SR4 | COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders. |
| M28505 | PF-06685249 | PF-06685249 (PF-249) is a potent and orally active allosteric AMPK activator with an EC50 of 12 nM for recombinant AMPK α1β1γ1. PF-06685249 can be used for diabetic nephropathy research. |
| M28504 | PF-06679142 | PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research. |
| M20630 | ex229 (compound 991) | EX229 (compound 991) is a potent AMPK activator that is 5-10-fold more potent than A769662 in activating AMPK. |
| M19445 | Kahweol | Kahweol inhibits adipogenesis and increase glucose uptake by AMP-activated protein kinase (AMPK) activation. Kahweol induces apoptosis. |
| M14836 | EB-3D | EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. |
| M13811 | ZLN024 hydrochloride | ZLN024 hydrochloride is an AMPK allosteric activator. ZLN024 directly activates recombinant AMPK α1β1γ1, AMPK α2β1γ1, AMPK α1β2γ1 and AMPK α2β2γ1 heterotrimer with EC50s of 0.42 µM, 0.95 µM, 1.1 µM and 0.13 µM, respectively. |
| M13808 | Buformin hydrochloride | Buformin hydrochloride (1-Butylbiguanide hydrochloride), a potent AMPK activator, acts as an orally active biguanide antidiabetic agent. |
| M13807 | Ampkinone | Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator. |
| M13806 | AICAR phosphate | AICAR phosphate (Acadesine phosphate) is an adenosine analog and a AMPK activator. |
| M13407 | YLF-466D | YLF-466Dis a novel AMPK activator that inhibits thrombin - induced platelet aggregation. |
| M7351 | Talampanel | Talampanel is a non-competitive AMPA/kainate antagonist. |
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