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Saikosaponin A is a COX-2 and iNOS inhibitor. Saikosaponin A Inhibits NF-κB, TNF-α, IL-1β and IL-6. Saikosaponin A suppresses osteoclastogenesis through inhibiting RANKL-induced p-38, ERK, JNK and NF-κB activation. Saikosaponin A can inhibit the expression of inflammatory‑associatied genes in hypertrophied 3T3‑L1 adipocytes and is a potent inhibitor of NF‑κB activation. Saikosaponin A has an anti-inflammatory effect by regulating inflammatory mediators and suppressing the MAPK and NF-κB signaling pathways in LPS-stimulated RAW 264.7 cells. Saikosaponin A has an inhibitory activity against allergic asthma.
| Molecular Weight | 780.98 |
| Formula | C42H68O13 |
| CAS Number | 20736-09-8 |
| Solubility (25°C) | DMSO |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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