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PF-06679142 

Cat. No. M28504

All AbMole products are for research use only, cannot be used for human consumption.

PF-06679142  Structure

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Quality Control & Documentation
Biological Activity

PF-06679142 (Compound 10) is a potent, orally active AMPK activator with an EC50 of 22 nM against α1β1γ1-AMPK. PF-06679142 can be used for diabetic nephropathy research.

Chemical Information
Molecular Weight 357.35
Formula C20H17F2NO3
CAS Number 1467059-66-0
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Tim F Ryder, et al. J Med Chem. Acyl Glucuronide Metabolites of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1 H-indole-3-carboxylic Acid (PF-06409577) and Related Indole-3-carboxylic Acid Derivatives are Direct Activators of Adenosine Monophosphate-Activated Protein Kinase (AMPK)

[2] David J Edmonds, et al. J Med Chem. Optimization of Metabolic and Renal Clearance in a Series of Indole Acid Direct Activators of 5'-Adenosine Monophosphate-Activated Protein Kinase (AMPK)

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Keywords: PF-06679142  supplier, AMPK, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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