Free shipping on all orders over $ 500

IMM-H007

Cat. No. M11462
IMM-H007 Structure
Size Price Availability Quantity
5mg USD 230  USD230 In stock
10mg USD 310  USD310 In stock
25mg USD 630  USD630 In stock
50mg USD 940  USD940 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK). Imm-h007 is a potential drug for the treatment of cardiac insufficiency. Imm-h007 negatively regulates endothelial inflammation by inactivating NF-κB and JNK/AP1 signaling. Imm-h007 can inhibit the degradation of ABCA1 (ATP binding cassette subfamily a member 1) and promote its cell surface localization in macrophages, thus promoting cholesterol efflux.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 485.45
Formula C22H23N5O8
CAS Number 1221412-23-2
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
Related AMPK Products
ASP4132

ASP4132 is an orally active, potent AMPK activator with an EC50 of 18 nM and anticancer activity that promotes tumor regression in a xenograft mouse model of breast cancer.

MK8722

Mk-8722 is a potent, direct, PAN-AMPK allosteric activator.

BC1618

BC1618, an orally active Fbxo48 inhibitor, stimulates Ampk signaling (preventing activated pAmpkα from being degraded by fBXO48-mediated proteasome). BC1618 promotes mitochondrial division, autophagy and insulin sensitivity in the liver.

O-304

O-304 is a pioneering, orally active pan-AMPK activator that increases AMPK activity by inhibiting dephosphorylation of pAMPK.

IM156

IM156, a metformin derivative, is an oxidative phosphorylation inhibitor that increases AMPK phosphorylation.

  Catalog
Abmole Inhibitor Catalog




Keywords: IMM-H007 supplier, AMPK, inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.