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Cat. No. M11462
IMM-H007 Structure
Size Price Availability Quantity
5mg USD 230  USD230 In stock
10mg USD 310  USD310 In stock
25mg USD 630  USD630 In stock
50mg USD 940  USD940 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK). Imm-h007 is a potential drug for the treatment of cardiac insufficiency. Imm-h007 negatively regulates endothelial inflammation by inactivating NF-κB and JNK/AP1 signaling. Imm-h007 can inhibit the degradation of ABCA1 (ATP binding cassette subfamily a member 1) and promote its cell surface localization in macrophages, thus promoting cholesterol efflux.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 485.45
Formula C22H23N5O8
CAS Number 1221412-23-2
Purity >98%
Solubility DMSO ≥ 60 mg/mL
Storage at -20°C
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Keywords: IMM-H007 supplier, AMPK, inhibitors

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