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Imm-h007 is an adenosine derivative that is an activator of the AMP-Activated Protein Kinase (AMPK). Imm-h007 is a potential drug for the treatment of cardiac insufficiency. Imm-h007 negatively regulates endothelial inflammation by inactivating NF-κB and JNK/AP1 signaling. Imm-h007 can inhibit the degradation of ABCA1 (ATP binding cassette subfamily a member 1) and promote its cell surface localization in macrophages, thus promoting cholesterol efflux.
| Molecular Weight | 485.45 |
| Formula | C22H23N5O8 |
| CAS Number | 1221412-23-2 |
| Solubility (25°C) | DMSO ≥ 60 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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