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Demethyleneberberine

Cat. No. M4407

All AbMole products are for research use only, cannot be used for human consumption.

Demethyleneberberine Structure
Size Price Availability Quantity
1mg USD 60  USD60 In stock
5mg USD 160  USD160 In stock
10mg USD 250  USD250 In stock
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Quality Control & Documentation
Biological Activity

Demethyleneberberine is a natural mitochondria-targeted antioxidant. Demethyleneberberine alleviates colitis and inhibits inflammation in mice by inhibiting the NF-κB pathway and regulating Th cell balance. Demethyleneberberine can be used as an AMPK activator in the study of non-alcoholic fatty liver disease (NAFLD).

Chemical Information
Molecular Weight 324.35
Formula C19H18NO4+
CAS Number 25459-91-0
Storage 4°C, protect from light, dry, sealed
References

[1] Jingfeng Liu, et al. Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway

[2] Saurabh Gupta, et al. Demethyleneberberine: A possible treatment for Huntington's disease

[3] Zehao Wang, et al. Demethyleneberberine promotes apoptosis and suppresses TGF-β/Smads induced EMT in the colon cancer cells HCT-116

[4] Miao Zhang, et al. Demethyleneberberine attenuates concanavalin A-induced autoimmune hepatitis in mice through inhibition of NF-κB and MAPK signaling

[5] Kun Wang, et al. The metabolism of berberine and its contribution to the pharmacological effects

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Keywords: Demethyleneberberine supplier, NF-κB, inhibitors, activators

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