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MK-3903

Cat. No. M9764
MK-3903 Structure
Size Price Availability Quantity
5mg USD 130  USD130 In stock
10mg USD 240  USD240 In stock
50mg USD 660  USD660 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

MK-3903 is a potent and selective AMPK activator (EC50 = 8 nM). MK-3903 binds moderately to the prostanoid DP2 (CRTH2) receptor (binding IC50=1.8 μM) but not in the presence of 10% human serum (binding IC50>86 μM).

In vivo, oral administration of MK-3903 (3, 10, and 30 mg/kg) to high-fructose fed db/+ mice results in significant inhibition of hepatic fatty acid synthesis (FAS) for all three doses.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 454.9
Formula C27H19ClN2O3
CAS Number 1219737-12-8
Purity >98%
Solubility DMSO ≥ 90 mg/mL
Storage at -20°C
References

[1] Ping Lan, et al. J Med Chem. Hit-to-Lead Optimization and Discovery of 5-((5-([1,1-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic Acid (MK-3903): A Novel Class of Benzimidazole-Based Activators of AMP-Activated Protein Kinase

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: MK-3903 supplier, AMPK, inhibitors

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