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Ginkgolide K

Cat. No. M10087
Ginkgolide K Structure
Size Price Availability Quantity
1mg USD 75  USD75 In stock
5mg USD 220  USD220 In stock
10mg USD 400  USD400 In stock
25mg USD 800  USD800 In stock
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Quality Control & Documentation
Biological Activity

Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K is isolated from Ginkgo biloba, it possesses neuroprotective activity.

Chemical Information
Molecular Weight 406.38
Formula C20H22O9
CAS Number 153355-70-5
Solubility (25°C) Soluble in DMSO
Soluble in ethanol
Storage 2-8°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Qin-Ying Li, et al. Int Immunopharmacol. Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis

[2] Wen-Bo Yu, et al. Int Immunopharmacol. The therapeutic potential of ginkgolide K in experimental autoimmune encephalomyelitis via peripheral immunomodulation

[3] Qiu Liu, et al. Mol Med Rep. Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways

[4] Wenbo Yu, et al. Cell Biol Toxicol. Ginkgolide K promotes the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells

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