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Ginkgolide K

Cat. No. M10087
Ginkgolide K Structure
Size Price Availability Quantity
10mg USD 400  USD400 In stock
25mg USD 800  USD800 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Ginkgolide K induces protective autophagy through the AMPK/mTOR/ULK1 signaling pathway. Ginkgolide K is isolated from Ginkgo biloba, it possesses neuroprotective activity.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 406.38
Formula C20H22O9
CAS Number 153355-70-5
Purity >99%
Solubility Soluble in DMSO
Soluble in ethanol
Storage 2-8°C, protect from light, dry, sealed
References

[1] Qin-Ying Li, et al. Int Immunopharmacol. Ginkgolide K supports remyelination via induction of astrocytic IGF/PI3K/Nrf2 axis

[2] Wen-Bo Yu, et al. Int Immunopharmacol. The therapeutic potential of ginkgolide K in experimental autoimmune encephalomyelitis via peripheral immunomodulation

[3] Qiu Liu, et al. Mol Med Rep. Ginkgolide K protects SH‑SY5Y cells against oxygen‑glucose deprivation‑induced injury by inhibiting the p38 and JNK signaling pathways

[4] Wenbo Yu, et al. Cell Biol Toxicol. Ginkgolide K promotes the clearance of A53T mutation alpha-synuclein in SH-SY5Y cells

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Keywords: Ginkgolide K supplier, Autophagy, inhibitors

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